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Tryptamines

Tryptamines. Pyrrole Ring. Benzine Ring. Indole Chemical Structure. Nitrogen. Phenethylamines. Aminoethyl group. Nitrogen. Benzine Ring. Psychedelics & Serotonin . Agonists = chemical that binds to a receptor of a cell and triggers a response by that cell

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Tryptamines

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  1. Tryptamines Pyrrole Ring Benzine Ring Indole Chemical Structure Nitrogen

  2. Phenethylamines Aminoethyl group Nitrogen Benzine Ring

  3. Psychedelics & Serotonin • Agonists = chemical that binds to a receptor of a cell and triggers a response by that cell • Agonists often mimic the action of a naturally occurring substance. • Example: psilocybin, DMT, mescaline and LSD are agonists at 5HT2A/2C receptors (serotonin) • MDMA releases serotonin from synaptic vesicles of neurons

  4. Psychedelic ≠ Iridescent

  5. Psychedelic • Means “mind manifesting” • Psyche = mind • Delos = manifesting • Can elicit high states marked by philosophic insights, mystical feelings, visions, and so forth • Coined by Humphry Osmond in his 1957 article "A Review of the Clinical Effects of Psychotomimetic Agents." • Reflects a positive bias toward these drugs

  6. Psychedelic Bias “I admire transpersonal psychotherapists. I think they are trying to remake the shamanistic institution in a modern form. What they have to realize is that they’re wasting their time unless they use the shamanistic tools. And the foremost tool of the shamans is the technique of ecstasy, and that means the hallucinogenic plants.” - Terence McKenna, The Archaic Revival

  7. The “O’gens” Empathogens • Causes or helps one to identify with the feelings of others or feel a sense of connectedness with others. empathy = identification with the feelings of others gen = creation

  8. The “O’gens” Entactogen • Generates a sense of "the touch within" Tactile = touch Gen = creation

  9. The “O’gens” Entheogen • Creates a sense of “becoming divine within” en = in / withintheo = spirit, Godgen = create, generate

  10. Altered States of Consciousness • “The spectrum of experiences other than ordinary waking consciousness, including daydreaming, trance, meditation, hypnosis, religious ecstasy and substance-induced states.”

  11. Hallucination Slade & Bentall (1988): “Any percept-like experience which (a) occurs in the absence of an appropriate stimulus, (b) had the full force or impact of the corresponding actual (real) perception, and (c) is not amenable to direct and voluntary control by the experiencer.”

  12. Are Hallucinogens Hallucinogenic? • Hallucinations are perceptions that have no basis in reality. • Hallucinations appear entirely realistic. • Psychedelics = a modification of regular perception • Psychedelics = awareness of the illusory and personal nature of the perceptions.

  13. Delusions: Definition A false belief based on incorrect inference about external reality that is firmly sustained despite what almost everybody else believes and despite what constitutes incontrovertible and obvious proof or evidence to the contrary. The belief is not one ordinarily accepted by other members of the person's culture or subculture. -- DSM-IV-TR

  14. Resource Tour • www.justice.gov/dea/pubs/abuse/8-hallu.htm • www.erowid.org • www.maps.org • www.heffter.org • http://www.beckleyfoundation.org/ • www.entheoguide.net • http://www.matrixmasters.net/salon/ Drop box on Angel – Add links!

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