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Is 24/7 necessary ?. Will Orr Royal Berkshire Hospital, Reading Clinical Lead, South Central Cardiovascular Network. NO CONFLICT OF INTEREST TO DECLARE . Is PPCI really so much better than good lysis?. One-year survival in Fast-MI (PPCI v Pharmacoinvasive).
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Is 24/7 necessary ? Will Orr Royal Berkshire Hospital, Reading Clinical Lead, South Central Cardiovascular Network
Is PPCI really so much better than good lysis? One-year survival in Fast-MI (PPCI v Pharmacoinvasive) Danchin, N. et al. Circulation 2008;118:268-276
100 miles PCI angiography only no cath lab South Central Cardiovascular Network Is 24/7 necessary ?
Is 24/7 necessary ? • Who is competent to do PPCI? • How important is time? • Who will decide?
Who is competent? Influence of Operator Volume on Outcome Adjusted odds ratios (OR) for major adverse cardiovascular events Moscucci, M. et al. J Am Coll Cardiol 2005;46:625-632
ns Who is competent? OR 0.65 (0.49-0.86) if > 325 PCI per year STEMI & NSTEMI Zahn Heart 2008;94:329–335
ns Who is competent? non-MI PCI Zahn Heart 2008;94:329–335.
South Central Cardiovascular Network * includes transfers from outside Trust sources: MINAP 07-08, Lead Interventionalists’ declared numbers
80 60 Absolute mortality reduction per 1000 treated patients 40 20 0 0 3 6 9 12 15 18 21 24 Treatment delay (h) Boersma et al : Lancet 1996; 348:771-775 How important is time? Early thrombolysis
How important is time? Primary PCI Time to treatment and 1-year mortality every 30 min delay increases mortality by 7.5% De Luca, G. et al. Circulation 2004;109:1223-1225
How important is time? % Mortality in NIAP
How important is time? % Mortality in NIAP
Potential to worsen outcome How important is time? Pinto Circulation 2006;114:2019-2025
Call-to-Balloon Time How important is time? Target 120 mins Door to balloon Call-to-Depart Travel
Call to Depart-the-scene timesSouth Central -MINAP 2006-2008 median 39 mins range 00:14:00 to 2:39:00 50% < 40 mins 90% < 60 mins 60 39
South Central Median 39:00 Call to Depart-the-scene timesSouth Central -MINAP 2006-2008 n = 333 range 00:14:00 - 02:39:00
Harefield • median 23 mins • 75% <30 mins • 90% <60 mins • no A&E Door-to Balloon times 30 mins
Call-to-Balloon Time “If we see centres getting >75% patients with PPCI centre D2B times <90 minutes with a median time of, say, 30-40 mins, then almost certainly this will reflect a good system with good outcomes.” “Similarly, if we see centres with >75% getting C2B times <120 mins, this will also represent a good system.”
Call-to-Balloon Time Target >75% C2B <120 mins Travel -10 mins Call-to-Depart >75% <40 mins Door to balloon >75% <90 mins
Call-to-Balloon Time Target >75% C2B <120 mins Travel how much less than 60 mins? Call-to-Depart median 30 mins Travel median 60 mins Door to balloon median 30 mins Similarly, if we see centres with >75% getting C2B times <120 mins, this will also represent a good system.
How important is time? 60 minute Isochrones ORH & SUHT
How important is time? 40 minute Isochrones ORH & SUHT
How important is time? Local service Centre Volume
Local service Centre Volume How important is time?
Who will decide? sources: MINAP 07-08, Lead Interventionalists’ declared numbers, Health Resource Group
Politicians DOH Acute Trusts Cardiologists BCIS Who will decide? Strategic Health Authority Cardiovascular Network Commissioners Media PPI groups The Public
Politicians DOH Acute Trusts Cardiologists BCIS Who will decide? Strategic Health Authority Cardiovascular Network Commissioners Media PPI groups The Public
Commissioners will decide • Concerns about Regional Service • significant extra costs • additional ambulance journeys/resources • 18% uplift in tariff at larger centres • unsure of size of health benefits • some areas currently have good outcomes from thrombolysis • areas with longer travel times • reluctant to decommission local services • knock-on effects on local cardiology provision • solution must be acceptable to PPI groups
South Central Cardiovascular Network Rules for Restricted Hours PPCI
Who will decide? X X X X X ? X