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Muscle Contraction. Skeletal muscle cell (myofiber). Sarcomere made of 2 types of filaments; myosin and actin filaments. Mechanism of contraction; sliding filament model. Cross-bridge cycle Cytosolic calcium At rest [Ca ++ ] = 10 -7 M Contraction [Ca ++ ] = 10 -5 M CBs cycle many times
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Sarcomere made of 2 types of filaments; myosin and actin filaments
Cross-bridge cycle Cytosolic calcium At rest [Ca++] = 10-7 M Contraction [Ca++] = 10-5 M CBs cycle many times during contraction CBs cycle asynchronously Sarcomere shortens from 2.5 mm to 1.5 mm as filaments slide Number of CBs attached is proportional to force