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Kidney Transplantation– Medical, Surgical, and Immunologic Considerations. Anil Kapoor, MD, FRCS(C) Associate Professor of Surgery McMaster University. OBJECTIVES. Transplant immunology Acute and Chronic Rejection How does a transplant program work ? Indications for renal transplant
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Kidney Transplantation– Medical, Surgical, and Immunologic Considerations Anil Kapoor, MD, FRCS(C) Associate Professor of Surgery McMaster University
OBJECTIVES Transplant immunology Acute and Chronic Rejection How does a transplant program work ? Indications for renal transplant Patient selection Technical/ Surgical considerations in renal transplant
Background DEMOGRAPHICS OF THE TRANSPLANT WAITING LIST TRANSPLANT DONOR & RECIPIENT WORK UP TRANSPLANT SURGERY TRANSPLANT IMMUNOLOGY ( REJECTION ) POST TRANSPLANT ISSUES HLA/ CROSS MATCH
Single kidney transplants by organ source, Canada, 1990-1999(Number) Source: CORR/CIHI 2001
Comparison of cadaveric organ donation rates, Canada and Provinces, 1998 -2000 (Rate per million population1) 1Crude rate Source: CORR/CIHI 2001
International comparison of cadaveric organ donation rates, 1999 (Rate per million population1) 1Crude rate. Sources: CORR/CIHI 2000; United Network for Organ Sharing (UNOS); Organizacion Nacional de Trasplantes in Spain; Australia & New Zealand Organ Donation Registry.
Cadaveric donor cause of death, Canada, 1999 1 Includes cerebrovascular accident, ruptured cerebral aneurysm and spontaneous cerebral haemorrhage. 2 Motor vehicle collision Source: CIHI/CORR 2001
Cadaveric donors by gender and average age, Canada, 1992-1999 Source: CIHI/CORR 2001
Actual cadaveric, potential cadaveric and living organ donors, Provinces, 2000 (Rate per million population1) 1Crude rate. Source: CIHI/CORR 2001