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Autonomic Nervous System

Autonomic Nervous System. Dr Dileep Verma Associate Professor Deptt of Physiology KGMU. Lecture-2 :Topics. Neurotransmitters of ANS Receptors of ANS - Adrenergic - Cholinergic.

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Autonomic Nervous System

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  1. Autonomic Nervous System Dr DileepVerma Associate Professor Deptt of Physiology KGMU

  2. Lecture-2 :Topics • Neurotransmitters of ANS • Receptors of ANS - Adrenergic - Cholinergic

  3. Learning Objectives • List different types of adrenergic & cholinergic receptors with their location • Various autonomic neurotransmitters. • Mechanisms of neurotransmitter release in the sympathetic and parasympathetic divisions.

  4. Autonomic nervous System • Neurotransmitters of ANS • Neurotransmitters of sympathetic nervous system • Neurotransmitters of parasympathetic nervous system

  5. Sympathetic Nervous System Neurotransmitters at- • Preganglionic nerve endings • Postganglionic nerve endings • Target tissue

  6. Sympathetic Nervous System Neurotransmitters at- • Preganglionic nerve endings • Acetylcholine (ACh) • Postganglionic nerve endings • Norepinephrine (NE) • Acetylcholine (ACh)

  7. Sympathetic Nervous System Neurotransmitters at- Target tissue • Epinephrine (Ep) • Norepinephrine (NE) • Acetylcholine (Ach)

  8. Parasympathetic Nervous System Neurotransmitters at- • Preganglionic nerve endings • Acetylcholine (ACh) • Postganglionic nerve endings • Acetylcholine (ACh)

  9. Autonomic nervous System Receptors of ANS • Receptors of Sympathetic Nervous System • Receptors of Parasympathetic Nervous System

  10. Autonomic nervous System Receptors of ANS • Receptors of Sympathetic Nervous System • Receptors of Parasympathetic Nervous System

  11. Autonomic nervous System Receptors of ANS • Receptors of Sympathetic Nervous System • Adrenergic Receptors • Cholinergic Receptors • Receptors of Parasympathetic Nervous System • Cholinergic Receptors

  12. Adrenergic Receptors • Alpha adrenergic • Alpha-1 (a1)- Excitatory • Alpha-2 (a2)- Inhibitory • Beta adrenergic • Beta-1(b1)- Excitatory • Beta-2 (b2) -Inhibitory • Beta-3 (b3)- Excitatory

  13. Alpha adrenergic receptor (a) • Alpha-1 (a1)- Excitatory • Vascular smooth muscles • Skin • Splanchnic region • GI wall • Sphincters • Radial muscle of iris • Alpha-2 (a2)- Inhibitory • Presynaptic nerve terminal • Platelets • GI wall

  14. Beta adrenergic receptor (b) • Beta-1(b1)- Excitatory • SA Node • AV Node • Myocardium • Beta-2 (b2) –Inhibitory • Vascular smooth muscles • Skeletal muscle • Bronchial smooth muscles • GI Wall • Beta-3 (b3)- Excitatory • Adipose tissue

  15. Cholinergic Receptor Cholinergic Receptors- 2 types • NicotinicReceptors (N) • Nicotinic Neuronal (NN) Type • Nicotinic Muscular (NM) Type • Muscarinic Receptors (M) • M1 to M7

  16. Nicotinic Neuronal (NN) Type • Location - Autonomic ganglia • Activated by- • Ach • Nicotine • Effect – Excitatory or Inhibitory • Blocked by- Hexamethonium

  17. Nicotinic Muscular (NM) Type • Location - Neuromuscular Junction • Activated by- • Ach • Nicotine • Effect – Always Excitatory • Blocked by- Curare

  18. Muscarinic receptor • Location - • Myocardium • Glands • Smooth muscle • Activated by- • Ach • Muscarine • Effect – Inhibitory/Excitatory • Blocked by- Atropine

  19. At Sweat Gland • Neurotransmitter-Acetylcholine • Receptors- Muscarinic • At the adrenal cortex • no postsynaptic neuron • Neurotransmitter-Acetylcholine • Receptors- Nicotinic

  20. 1- Sympathetic postganglionic fibres to sweat gland secrete-- Acetylcholine Norepinephrine Epinephrine Serotonin

  21. 2-Acetylcholine through nicotinic receptors causes-- Constriction of pupil Secretion of saliva Decreases the heart rate Contraction of skeletal muscle

  22. 3-.Stimulation of alpha adrenergic receptors results in- Pupillary dilatation Glycogenolysis Inhibit intestinal motility All of the above

  23. 4. a1adrenergic receptors are located on/in Presynaptic nerve terminal Platelets GI wall Radial muscle of iris

  24. 5-Which is true about b3adrenergic receptors ? Located on adipose tissue More sensitive to epinephrine Stimulate glycogenesis Inhibits lipolysis

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