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Your Questions ??

Answers to MiniQuiz 4:. Your Questions ??. α -bromoethylbenzene. Quartet 1:3:3:1 !. Score: 2*/2. α -dibromoethylbenzene: one singlet and groups of aromatics. Today: “Esterification” Grignard reactions MiniQuiz Next Tuesday, March 10: Conclusion of Grignard.

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Your Questions ??

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  1. Answers to MiniQuiz 4: Your Questions ?? α-bromoethylbenzene Quartet 1:3:3:1 ! Score: 2*/2 α-dibromoethylbenzene: one singlet and groups of aromatics

  2. Today: • “Esterification” • Grignard reactions • MiniQuiz • Next Tuesday, March 10: Conclusion of Grignard. • MiniQuiz on today’s class • Following Tuesday 3/17: Your questions. Introduction to Unknowns. • Midterm 2:10 – 4pm in your lab • (5 Problems. Total: 100 Pts.) Do Sample Midterms (in eres file; password!). Review/study labs with calculations and problems and our lab lectures.

  3. Methyl Benzoate Synthesis An equilibrium! Keq=3.0

  4. Our Esterification Procedure • What are the advantages of "boiling under reflux”? • What was the purpose of each of the following extraction steps: • rinsing with water • then extracting with sodium bicarbonate solution • extracting with sat. sodium chloride solution? • In our extraction with ether, which was the organic layer, top or bottom? • 4. What would the H-NMRs of methyl benzoate and of benzoic acid look like?

  5. Grignard • What is a "Grignard reagent“? • Properties of Grignard reagents? • Which products do you obtain from the reaction of a Grignard reagent with a carbonyl group followed by hydrolysis? • from an aldehyde…from a ketone…from an ester… ? • What type of a reaction is it ….? • Reaction of RMgX with water…?

  6. Victor Grignard found that, in the presence of ether, magnesium reacts with alkyl and aryl halides at room temperature to form organomagnesium compounds. For this discovery he was awarded the 1912 Nobel Prize in Chemistry.

  7. RMgX – Ether Complex

  8. Grignard reagents are metal-organic compounds. Other examples of metal-organic compounds? Are there any in nature? Chlorophyll a

  9. Grignard Our multistep synthesis of triphenyl methanol, starting with the synthesis of our Grignard reagent: Grignard Adduct DRY! DRY!

  10. Write the structure of the product obtained if our Grignard reagent reacts with a) water b) methanol c) benzoic acid d) carbon dioxide e) acetone f) formaldehyde

  11. TLC • Thin Layer Chromatography is an example of chromatography. • Do you know other types of chromatography? • What is common to all types of chromatography?

  12. TLC What is the moving phase, the stationary phase in our TLC? What type of information do we expect from our TLC?

  13. Next Tuesday: Conclusion of Grignard. MiniQuiz on today’s class!

  14. MiniQuiz 5 Problems: • Draw the structure of a diene(your choice) that would work well in a Diels-Alder reaction. • Draw the structure of a dienophile that would work well in a Diels-Alder reaction.

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