240 likes | 254 Views
EFFECT OF ATYPICAL POPULATIONS IN META-ANALYSIS. Juliana Torres Sánchez PhD. Juan Carlos Correa Morales. AGENDA. Contextualization Problem Design and methods Data/results Next steps…. Contextualization. Sum.
E N D
EFFECT OF ATYPICAL POPULATIONS IN META-ANALYSIS Juliana Torres Sánchez PhD. Juan Carlos Correa Morales
AGENDA • Contextualization • Problem • Design and methods • Data/results • Next steps….
Contextualization Sum • The meta-analysis is a statistical technique that allows the sum of different studies, to obtain conclusions allowing the unification of results, helping for the understanding of the response variable being analyzed. StatisticalTechnique Understanding Response variable Unification
Problem • Effect Atypical Study Results • Recommendations • Mean, proportions
Studies Meta- Analysis Design and methods µp + k σp Meta-analysis size = N = Sample Size = n 10 Studies + Outlierstudy N = 11 1.000 simulations Proportion (%) = # No Heterogeneity 1.000 Simulations
Design and Methods Atypicalpopulation
In when Not Increase the doses Decrease the doses
Out when Yes Decrease the doses True True Increase the doses
¿Is that or those atypical studies really part of your population
A good approach is to use the linear regression outlier detection proposals
Next steps…. • Othermodels randomeffectsmodel mixedeffectsmodel