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Nanovaccine Platform Technology: A New Paradigm

Nanovaccine Platform Technology: A New Paradigm. Balaji Narasimhan Department of Chemical and Biological Engineering Presented by: Sarah A. Rajala, Dean, College of Engineering. Why the Urgency?. Re-emergence of known diseases and rapid emergence of new diseases

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Nanovaccine Platform Technology: A New Paradigm

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  1. Nanovaccine Platform Technology: A New Paradigm Balaji Narasimhan Department of Chemical and Biological Engineering Presented by: Sarah A. Rajala, Dean, College of Engineering

  2. Why the Urgency? • Re-emergence of known diseases and rapid emergence of new diseases • Need to improve existing vaccines (e.g., 2012-13 influenza vaccine) • Antibiotic resistance • Unsustainable healthcare system • Therapeutics cost 20-1,000 times more than prevention technologies per healthcare $$ spent FUTURE? PRESENT

  3. Vision: Nanovaccines will revolutionize our ability to prevent and treat disease • Bridge groundbreaking science with novel nanoscale platform technologies • Science-driven, first principles paradigm for vaccine design • Novel nanomedicine-driven platform technology for tomorrow’s vaccines • Inherently interdisciplinary • Systemsapproach encompassing bench-to-bedside considerations from the earliest stages of conceptualization

  4. Competitive Edge and Differentiators • Systems approach to vaccine design • Design, delivery, and deployment • Technology niche • Needle-free • Single dose • No refrigeration • Combination therapies • Bench-to-bedside • Partnerships with universities, government laboratories, and industry Images: Courtesy Johns Hopkins, Ideo, Ohio State, Mystic Pharmaceuticals, and Atlantis Online

  5. Room Temperature Nanovaccines • Today’s vaccines need to be refrigerated • Refrigeration is a major component of the cost and a significant logistical roadblock • Innovation: exploit advances in materials science and nanotechnology to design a thermally stable subunit nanovaccine • Nanovaccine can be stored at room temperature or higher for up to one year and still maintain efficacy Petersen et al, Mol Pharmaceutics (2012)

  6. Tomorrow’s Nanovaccines? Video courtesy of Mystic Pharmaceuticals

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