1 / 11

Metabolic/Inflammatory/CVS & Nutrition Add-ons to MAS (and OATS)

Metabolic/Inflammatory/CVS & Nutrition Add-ons to MAS (and OATS). Julian Trollor, Evelyn Smith. The Model. The People. MAS & OATS Investigators, Staff & participants Evelyn Smith (post-doctoral) Key collaborators Lesley Campbell & Katherine Samaras ( Garvan ) Bernhard Baune (JCU)

woods
Download Presentation

Metabolic/Inflammatory/CVS & Nutrition Add-ons to MAS (and OATS)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Metabolic/Inflammatory/CVS & NutritionAdd-ons to MAS (and OATS) Julian Trollor, Evelyn Smith

  2. The Model

  3. The People • MAS & OATS Investigators, Staff & participants • Evelyn Smith (post-doctoral) • Key collaborators • Lesley Campbell & Katherine Samaras (Garvan) • Bernhard Baune (JCU) • Stephen Lord, Jackie Close, Alfred Wong (NeurA) • Jayashree Arcot (UNSW Nutrition) & Sharon Ong (PhD Scholar) • Sam Breit & David Brown (St Vincents Centre for Applied Medical Research) • Diane Fatkin (Victor Chang) • Paul Mitchell and Jie Jin Wang (Westmead)

  4. MAS • Bloods from Wave 1 & 2 (most participants) • Inflammatory markers • insulins • Lab assessments wave 2 (half of the participants) • anthropometric measures • CVS: Arterial stiffness, ECG, tilt BP • Retinal photography • Lab assessments wave 3 (aiming for half of the participants) • anthropometric measures • CVS: Arterial stiffness, ECG

  5. Outputs: MAS Wave 1Planned or In Progress

  6. Outputs: MAS Wave 1Potential

  7. Outputs: MAS Wave 2Potential

  8. Systemic Inflammation and Cognition in the Elderly. Neuropsychiatric Disorders. Miyoshi K (ed) Springer • Systemic inflammation is associated with MCI and its subtypes – the Sydney Memory and Aging Study • Our findings suggest an association between specific inflammatory markers and MCI subtypes, highlighting sex differences in the association with MCI • Accepted Dementia and other Cognitive disorders • The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study • markers of systemic inflammation are related to cognitive deficits in a non-clinical community-dwelling elderly population, independent of depression, cardiovascular or metabolic risk factors, or presence of apolipoprotein ε4 genotype. • Submitting to Age

  9. The relationship between adiposity and cognition, MCI and its subtypes – the Sydney Memory and Ageing Study • In progress: underweight is associated with lower cognition, whereas obesity is associated with high cognitive scores • The association of diabetes, impaired fasting glucose and insulin resistance with cognition, MCI and its subtypes: the Sydney Memory and Ageing study • In progress: Diabetes is associated with lower cognition. IFG is not. Insulin resistance is common in AD, is it more common in amnestic MCI? Yes

  10. Depression, inflammation and cognition • Inflammation is associated with impaired mood • Inflammation negatively impacts on general functioning in the elderly • Inflammation mediates the relationship between mood and cognitive performance

  11. Opportunities • 2 ILPs for 2011 • Inflammation and Cognition PhD • Lots of data, open to group use

More Related