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1. Metalation of p -Excessive Heteroaromatics

Explore the reactivity of heteroaromatic compounds, such as furans, thiophenes, pyrroles, and indoles, through metalation processes. Discover the diverse synthetic uses of metalated compounds in the formation of various heterocycles.

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1. Metalation of p -Excessive Heteroaromatics

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  1. 1. Metalation of p-Excessive Heteroaromatics

  2. Thermodynamic Acidities of π - Excessive Heteroaromatics

  3. Kinetic Acidities ofπ - Excessive Heteroaromatics.

  4. Synthetic Use of Metalated non-DMG Furans and Thiophenes. Conversions into other Heterocycles

  5. Synthetic Use of Metalated non-DMG Furans and Thiophenes. Oxidative Pathways

  6. Metalated Furans. Additions on Glycosyl Nitrones

  7. Use of Metalated non-DMG Thiophenes. Historical Industrial Practice

  8. Directed ortho Metalation (DoM) Reactivity of Furans and Thiophenes

  9. DoM Chemistry of Furans and Thiophenes. Carbon-Based DMG’s. DMG = 2-oxazolino

  10. DoM Chemistry of Furans. DMG = CON-R. Application

  11. DoM Reactivity of Furans and Thiophenes. Dianion Equivalents with Carbon-based DMGs

  12. DoM Reactivity of Furans and Thiophenes. “DMG” = CO2-

  13. DoM Chemistry of Furans. DMG = CH2O-

  14. DoM Chemistry of Furans and Thiophenes. Heteroatom - Based DMGs, DMG = SO2R

  15. DoM Reactivity of N-DMG Pyrroles

  16. DoM Reactivity of N-DMG Pyrroles

  17. DoM Reactivity of Indoles. N - DMGs

  18. DoM Reactivity of Indoles. N-DMG = CO2t-Bu. Indirect C-7 Substitution

  19. DoM Reactivity of Indoles. Non-N DMG Indoles. DMG = CONR2

  20. DoM Reactivity of Indoles. Non-N DMG Indoles. DMG = CH2NR2

  21. DoM Reactivity of Non-N DMG Indoles. DMG = OCONEt2. Benzenoid Ring Functionalization

  22. DoM Reactivity of p-Excessive Heteroaromatics. Pyrrazoles. N DMGs

  23. DoM Reactivity of Pyrrazoles. Non-N DMGs. DMG = SO2N-R

  24. DoM Reactivity of Pyrrazoles. Total Synthesis Application

  25. Metalation Reactivity of Imidazoles

  26. DoM Reactivity of Imidazoles. DMG = N-SO2NR2. Silicon Protection

  27. DoM Reactivity of Imidazoles in Context of Nucleosides

  28. DoM Reactivity of Oxazoles

  29. Metalation Reactivity of Thiazoles

  30. Metalation and DoM Reactivity of Methyl Substituted Oxazoles and Thiazoles

  31. DoM Reactivity of Aminoisoxazoles

  32. DoM Reactivity of 1-Substituted 1,2,4-Triazoles

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