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E:Med

E:Med. Martin Vingron’s group. Jose M Muino. Martin Vingron’s group. Sequence alignment Microarray gene analysis Gene regulation and evolution: (combinatorial) TF DNA binding prediction Histone modification  gene expression Factors affecting mutation rates. My projects:.

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E:Med

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  1. E:Med Martin Vingron’s group Jose M Muino

  2. Martin Vingron’s group • Sequence alignment • Microarray gene analysis • Gene regulation and evolution: • (combinatorial) TF DNA binding prediction • Histone modification  gene expression • Factors affecting mutation rates

  3. My projects: • (RSE1): • Regulation of recombination initiation by epigenetic factors in response to stress • Environment => Epigenetics => DNA breaks • CancerEpisys: • Epigenetics in Chronic Lymphocytic Leukemia

  4. TFs => DNA methylation Motifs overrepresented in hypomethylated regions: Clustering of overrepresented motifs […] Cis-regulatory module (ZNF423 + EBF1) Hypomethylated regions Predicted affinity of EBF1 correlates with change in DNA methylation Objective: *To obtain pairs of TF and target regions that influence epigenetic status *Why the miss-regulation?: Miss-regulation TF complex Mutations Needed: *DNA met. & gene expression & SNPs *Experimental validation

  5. DNA methylation => TF binding • Objective: • To find pairs of TF  target genes which coexpression is dependent of DNA methylation • Needed: • DNA met. & gene expression in same individuals

  6. Epigenetics=> genetic mut. • Objective: • Does epigenetics affect genetic mut.? • What happen first? • Environment=>epigenetics=>mut.(?) • Needed: • DNA met & mutations same individuals • Experimental validation Hypo-methylated Hyper-methylated

  7. Web-tool for ChIP-seq analysis • User-friendly • All public plant ChIP-seq (-chip) data available • Compatible with Integrated Genome Browser • Compatible with Galaxy

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