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gDNA

gDNA. gDNA. gDNA. cDNA. cDNA. cDNA. Sub. Sub. Sub. A. B. C. Figure(E)F-1:

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gDNA

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  1. gDNA gDNA gDNA cDNA cDNA cDNA Sub Sub Sub A B C Figure(E)F-1: Confirmation of maternal imprinting by sequence analysis of both genomic (gDNA) and cDNA sequence of exon 5 of SGCE. Panel A and B show maternal imprinting and inheritance of the healthy paternal allele (IV:115 and V:66), which is demonstrated by a normal sequence in the cDNA of exon 5 of SGCE. Panel C represents the maternal imprinting and inheritance of the affected paternal allele (V:1) which results in a 2 bp deletion in both the genomic and cDNA sequence of exon 5 of SGCE. The substracted sequence (Sub) represents the subtraction of the affected sequence from a normal sequence which more clearly demonstrates the deletion in the sequence.

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