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Interventions for Tuberculosis Control and Elimination

Interventions for Tuberculosis Control and Elimination Slides from the web site http://www.tbrieder.org Compiled by: Hans L Rieder. Brick kindly provided by Reuben Granich. Pot kindly provided by Liisa Parkkali. The Area of the “Magic Mountain”.

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Interventions for Tuberculosis Control and Elimination

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  1. Interventions for Tuberculosis Control and Elimination Slides from the web site http://www.tbrieder.org Compiled by: Hans L Rieder

  2. Brick kindly provided by Reuben Granich

  3. Pot kindly provided by Liisa Parkkali

  4. The Area of the “Magic Mountain”

  5. Children with Tuberculosis at the Springfield House Open-Air School, Clapham Common, London, November 1932 Jacobson C. Lancet 2001;358:340 Photo: Hutton Getty

  6. With the input from Enarson DA, October 6,2006

  7. Transmission Chemotherapy Doctor’s delay Prophylactic treatment Preventive therapy Patient’s delay Infectious tuberculosis Sub-clinical infection Exposure Death Non-infectious tuberculosis BCG vaccination

  8. Chemotherapy

  9. Transmission Chemotherapy Doctor’s delay Prophylactic treatment Preventive therapy Patient’s delay Infectious tuberculosis Sub-clinical infection Exposure Death Non-infectious tuberculosis BCG vaccination

  10. Chemical Structure of Isoniazid O NH-NH 2 C N Meyer H, Mally J. Monatshefte Chemie 1912;33:393-414

  11. O NH-NH 2 C Model of Isoniazid Action Isoniazid N Passive diffusion KatG activation Antagonists Reactive oxygen/ organic radicals Efflux NAT? AhpC? Multiple targets DNA damage? NAD metabolism? Mycolic acid synthesis InhA, KasA Zhang Y, et al. In: Hatfull GF, et al. Molecular Genetics of Mycobacteria, 2000

  12. Chemical Structure of Rifampicin CH CH 3 3 OH OH OOCC H O H C 3 3 CH 3 OH OH H C NH 3 H CO 3 CH 3 N N-CH CH=N 3 O OH O O CH 3 Maggi N, Pasqualuci C, Ballotta R, Sensi P. Chemotherapy 1966;11:285-92

  13. Bioavailability of 600mg Rifampicin by Excipient and Manufacturing Process in Healthy Volunteers 15 Reference 10 Mean serum level (mg/L) 5 Change of excipient and manufacturing process 0 0 1 2 3 6 9 Hours after administration Cavenaghi R. Bull Int Union Tuberc Lung Dis 1989;64(1):36-7

  14. Chemical Structure of Pyrazinamide O N C NH 2 N Kushner S, et al. Am J Chem Soc 1952;74:3617

  15. Chemical Structure of Ethambutol H C C C CH OH 3 2 H H 2 NH . (CH ) 2HCl 2 2 NH H C C C CH OH 3 2 H H 2 Thomas JP, et al. Am Rev Respir Dis 1961;83:891-3

  16. TABLE III. Comparative Bacteriostatic Spectra of Streptomycin and Streptothricin. On basis of crude, ash-free dry material. Schatz A, Bugie E, Waksman SA. Proc Soc Experiment Biol Med 1944;55:66-9

  17. Chemical Structure of Streptomycin NH H NH NCNH H 2 NCNH 2 O OH CHO O OH H C 2 OH HO O HO O HO H C 2 H CNH 3 Schatz A, Bugie E, Waksman SA. Proc Sco Exper Biol Med 1944;55:66-9 OH

  18. TABLE III. Comparative Bacteriostatic Spectra of Streptomycin and Streptothricin. On basis of crude, ash-free dry material.

  19. Chemical Structure of Thioacetazone O H C C N H N N C NH 3 2 H H C S Domagk G. Naturwissenschaften 1946;33:315

  20. Tuberculosis Patient in Malawi with Thioazetazone-Associated Toxic Epidermal Necrolysis Photo courtesy: Tone Ringdal

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