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Sequence Harmony Identifies Subtype-Specific Sites

This study explores how Sequence Harmony can identify subtype-specific sites in the Smad family, shedding light on differences between subfamilies in signalling pathways. Results and conclusions are provided, along with theory and methodology.

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Sequence Harmony Identifies Subtype-Specific Sites

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  1. Interaction Interaction SH = 0 SH = 0 £  SH SH 0.2 0.2 10 b b T T R R - - I/BMPR I/BMPR - - I/ALK1/2 I/ALK1/2 7 8 9 c c - - Ski/SnoN Ski/SnoN 5 5 7 7 SARA/Mixer/FAST1 SARA/Mixer/FAST1 10 10 10 10 Total Total ‘ ‘ functional functional ’ ’ 23 22 27 26 Unknown function Unknown function 10 9 13 14 Total Total 32 32 40 40 <title Sequence Harmony Identifies Subtype-Specific Sites> <Jane Author>, <John Q. Author> andJaap Heringa Centre for Integrative Bioinformatics VU (IBIVU), Vrije Universiteit Amsterdam • Introduction • The Smad family <…> • <…> help to explain differences between the subfamilies. • Conclusions • Concluding, sites of low Sequence Harmony <…> • <…> signalling pathways. • Results • The Smad family <…> • <…> help to explain differences between the subfamilies. Table1|Sequence Harmony selects <…> the Smad-MH2 alignment. • Theory • The Sequence Harmony <…> follows:<…> entropy of both groups. Figure 1|ROC plots <…> also shown.

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