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Post thrombotic Syndrome

Post thrombotic Syndrome. Godwin Tse LA-TRAP Winter 2011. What is post-thrombotic syndrome?.  Long-term complication of deep venous thrombosis (DVT) that is characterized by chronic, persistent pain, swelling and other signs in the affected limb Caused by damage to veins and valves.

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Post thrombotic Syndrome

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  1. Post thrombotic Syndrome Godwin Tse LA-TRAP Winter 2011

  2. What is post-thrombotic syndrome? •  Long-term complication of deep venous thrombosis (DVT) that is characterized by chronic, persistent pain, swelling and other signs in the affected limb • Caused by damage to veins and valves

  3. Signs and Symptoms Signs • Edema • Eczema • Hyperpigmentation • Redness • Secondary varicose veins • Lipodermatoschlerosis (LDS) • Venous Ulcers Symptoms • Heaviness • Pain • Swelling • Itching • Cramps • Aching • Symptoms worsen with activity and standing

  4. Post thombotic syndrome DVT

  5. Risk factors • Age >65 • Sex • Location of DVT • Recurrent DVT • Lack of long-term anticoagulation • Obesity

  6. Prevention • DVT Prophylaxis • Optimal duration of anticoagulation After initial DVT: • Prevention of recurrent DVT • Compression stockings

  7. Treatment • Compression stockings/pump • Elevation of extremity while resting • Lifestyle changes • Medications

  8. PTS vs recurrent DVT Over 24h span (DVT): • Dramatic onset of pain • Persistent swelling • Duplex ultrasound • May difficult to distinguish due to abnormalities still present in the venous segment

  9. Social impact • Costs • Increased medical costs • Lost of productivity at work/home • Decreased quality of life

  10. References • http://www.stoptheclot.org/natt_publications/post_thrombotic_syndrome.pdf • http://www.venousdiseasecoalition.org/diseaseinfo/pts/ • http://www.ncbi.nlm.nih.gov/pubmed/12163001 • http://dermatology.cdlib.org/143/case_presentations/postthrombotic_syndrome/vereecken.html • http://www.inate.org/en/1/2/6/23/default.aspx#Whatispostthromboticsymdrome • http://emedicine.medscape.com/article/461449-overview • http://www.fvleiden.org/ask/82.html • http://circ.ahajournals.org/cgi/content/full/121/8/e217

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