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Favours antibiotics. Favours placebo. Study. Treatment failures (No of Events/Total No). Odds ratio (95% CI). Antibiotics. Placebo. 4/42. 4/41. Elmes 1957. 0.97 (0.23-4.18). 0/26. 5/27. Berry 1960. 0.08 (0.00-1.47). 5/15. 12/15. Pines 1968. 0.13 (0.02-0.66).
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Favours antibiotics Favours placebo Study Treatment failures (No of Events/Total No) Odds ratio (95% CI) Antibiotics Placebo 4/42 4/41 Elmes 1957 0.97 (0.23-4.18) 0/26 5/27 Berry 1960 0.08 (0.00-1.47) 5/15 12/15 Pines 1968 0.13 (0.02-0.66) 58/176 53/86 Pines 1972 0.31 (0.18-0.52) 28/59 19/57 Anthonisen 1987 1.81 (0.85-3.83) 24/176 79/159 Allegra 1991 0.16 (0.09-0.27) 4/61 6/29 Alonso Martinez 1992 0.27 (0.07-1.04) 49/132 49/136 Jorgensen 1992 1.05 (0.64-1.72) Test for heterogeneity χ2=50.53, I2=82%, p<0.001 0.01 0.1 1 10 4/40 2/21 Sachs 1995 1.06 (0.18-6.30) Odds ratio (95% CI) 3/47 16/46 Nouira 2001 0.13 (0.03-0.48)