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About OMICS Group

About OMICS Group.

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About OMICS Group

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  1. About OMICS Group OMICS Group International is an amalgamation of Open Access publications and worldwide international science conferences and events. Established in the year 2007 with the sole aim of making the information on Sciences and technology ‘Open Access’, OMICS Group publishes 400 online open access scholarly journals in all aspects of Science, Engineering, Management and Technology journals. OMICS Group has been instrumental in taking the knowledge on Science & technology to the doorsteps of ordinary men and women. Research Scholars, Students, Libraries, Educational Institutions, Research centers and the industry are main stakeholders that benefitted greatly from this knowledge dissemination. OMICS Group also organizes 300 International conferences annually across the globe, where knowledge transfer takes place through debates, round table discussions, poster presentations, workshops, symposia and exhibitions.

  2. About OMICS Group Conferences OMICS Group International is a pioneer and leading science event organizer, which publishes around 400 open access journals and conducts over 300 Medical, Clinical, Engineering, Life Sciences, Phrama scientific conferences all over the globe annually with the support of more than 1000 scientific associations and 30,000 editorial board members and 3.5 million followers to its credit. OMICS Group has organized 500 conferences, workshops and national symposiums across the major cities including San Francisco, Las Vegas, San Antonio, Omaha, Orlando, Raleigh, Santa Clara, Chicago, Philadelphia, Baltimore, United Kingdom, Valencia, Dubai, Beijing, Hyderabad, Bengaluru and Mumbai.

  3. Therapeutic Potentials of Plant Extracts with reference to Anti-obesity Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China Name of the Speaker: MandaviDeshpande-Garge Research Center: APT Research Foundation, S. No.36/1/1,M.N.199, VadgaonKhurd, Sinhagad Road, Pune 411 041, Maharashtra, India.

  4. Introduction • Nature a Great Chemist • Ancient Science of Ayurveda & Unani • Around 120 drugs originated from Plants • Chemically synthesized drugs • Standardization of chemically synthesized drugs • Efficacy studies of these drugs Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  5. Use of Plant Originated Drugs Ref: Plant-Based Drugs and Medicines by Leslie Taylor Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  6. Use of Plant Extracts contd.. Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  7. Diseases Associated with Obesity • Diabetes (Ref.: NIH,USA) • Cardiovascular Diseases (Ref.: NIH,USA) • Cancer of Oesophagus, Pancreas, Colon and Rectum, Breast (after menopause), Endometrium (lining of the uterus), Kidney, Thyroid, Gallbladder, (Ref.: NCI, NIH,USA) • Infertility (Ref.: NIH,USA) • Inflammation (Ref.: NIH,USA) Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  8. Lipid Metabolism Source: Part Three: Ray medina, Dietary Fat, Chylomicrons and Endotoxemia Published November 26, 2012. Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  9. Probable Mechanisms for Anti-Obesity Activity • ↓ Lipid absorption • ↓ Energy intake • ↑ Energy expenditure • ↓ Pre-adipocyte differentiation and proliferation • ↓ Lipogenesis and ↑ lipolysis Ref: Jong Won Yun, Possible anti-obesity therapeutics from nature – A review Phytochemistry 71 (2010) 1625–1641. Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  10. Plant materialZiziphusmauritiana (Ber) Authentication certificate Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  11. Quantitative Phytochemical Analysis of Ziziphusmauritianabark powder (ZMBP) extracts. Tannins : Adipocyte differentiation inhibitor Flavonoids : Increase Glucose uptake Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  12. Anti-Oxidant Activity % Inhibition of ABTS+ oxidation by ZMBP Extracts Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  13. Lipase Inhibitory Activity % inhibition of Porcine Pancreatic Lipase activity by ZMBP Aqueous Extract Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  14. In Vitro StudiesCell Viability Assay in L929 cell line Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  15. In Vitro Studies 3T3-L1 Adipocyte Differentiation assay (Magnification 40X) Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  16. Glut 4 Translocation Assay in CHO-HIRC-muc-GLUT4eGFP cells Vehicle Control 50 nM Insulin stimulation 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China C-10 micro g/ml C-50 micro g/ml

  17. Glucose Uptake Assay in CHO-HIRC-muc-GLUT4eGFP cells Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China z

  18. In Vivo Studies Development of Obese B6D2F1 mice • High Fat Diet for 30 days • Dosing the animals (n=6) for 30 days at 100 mg/kg body weight, orally with ZMBP Aqueous extract (ZMBPE aq.) & Standard drug Orlistat 7.8 mg/kg Monitoring of Obesity parameters • Body weight, Anthropometry, Insulin resistance on day 0 and day 30 • Weight of Peritoneal and Epididymal Fat Pad Tissue Triglycerides Determination • Tissue Triglycerides Determination • Pancreatic Lipase activity Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  19. In Vivo StudiesAnti-Obesity Activity in Mice: Body Weight Data *= P<0.05, ***=P<0.001 Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  20. In Vivo Studies Effect of ZMBPE aq. on Diet Induced Obese Mice Body Weight Data and Anthropometrical Parameters **=p<0.01, ***=p<0.001 Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  21. In Vivo StudiesEffect of ZMBPE aq. on Diet Induced Obese Mice Normal Control Obese Control ZMBPE aq. Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  22. In Vivo Studies Effect of ZMBPE aq. on Diet Induced Obese Mice : Lipid Profile, Tissue triglycerides and Faecal Fat/ Pancreatic Lipase Analysis Lipid Profile Tissue Triglyceride content Faecal fat and pancreatic lipase analysis Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  23. Summary • All extracts showed Anti-oxidant activity • The ZMBPE Aq. showed Lipase inhibitory activity • ZMBPE Aqinhibited the pre-adipocytes differentiation induced by IBMX + insulin. • It also showed Insulin-like glucose transport stimulatory activity in CHO-HIRC-muc-GLUT4eGFP cells. • In the present studies we have observed reduction in body weight gain, decrease in triglyceride content, decrease in pancreatic lipase activity associated with increasedfaecal lipid excretion in ZMBPE Aq. fed obese mice. Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  24. Acknowledgement • Dr. P. B. Parab and Dr. K. G. Apte, APT Research Foundation Pune, Maharashtra, India. • Dr. Vijayakumar and Dr Manoj Kumar Bhat, of National Centre For Cell Sciences, Pune, Maharashtra, India. • All Staff, National Toxicology Centre and APT Research Foundation, Pune, Maharashtra, India. Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  25. THANK YOU Date: 26/08/2014 2nd International Conference on Pharmacognosy, Phytochemistry and Natural Products, 25-27 August 2014, Beijing, China

  26. Lets Meet again at Pharmacognosy-2015 3rd International Conference and Exhibition on Pharmacognosy, Phytochemistry and Natural Products October 26-28, 2015 Hyderabad, India Theme: Advanced trends for the future of Herbal Drugs and Products Website:http://pharmacognosy-phytochemistry-natural-products.pharmaceuticalconferences.com/

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