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multiple sclerosis

multiple sclerosis. skler-O-sis. Neuron Structure. Dendrites (receive impulse). Cell Body (metabolic functions and “decisions”). Axon (carries impulse Away from cell body toward target). Schwann Cell (Insulates, protects, nourishes).

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multiple sclerosis

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  1. multiple sclerosis skler-O-sis

  2. Neuron Structure Dendrites(receive impulse) Cell Body(metabolic functions and “decisions”) Axon(carries impulse Away from cell body toward target) Schwann Cell(Insulates, protects, nourishes) Node of Ranvier(between Schwann cells; place for signal to jump) Synaptic Terminal(signal converted to chemical)

  3. Myelination and the Schwann Cells • The myelin acts as electricial insulator. • As the cells grow, they wrap around the axon. • The more insulation there is, the faster the impulse will travel down the axon.

  4. multiple sclerosis • autoimmune (immune system attacks self) • attacks myelin sheath around neurons • leaves scar tissue and hardened (sclerosed) areas • brain interprets this as pain

  5. multiple sclerosis • symptoms • chronic or relapsing pain, tingling, burning sensation • usually lasts many years • extremely variable progression • might need wheelchair in 5 yrs, 20 yrs, or not at all • increasing handicap over years • might eventually lose use of legs, bowels, bladder

  6. multiple sclerosis • don’t know why it happens • we do know how it works • no cure • but you should be able to suggest a possible treatment.... • cortisol – because it suppresses the immune system • some areas of world more common

  7. MS risk • more common the further away from equator • possible connection with vit D and immune system regulation?

  8. SSPE • subacute sclerosing pan-encephalitis • rare: 1 in 100 000 of those infected with measles • stage 1: • erratic behavior • mental deterioration • dysphagia (difficulty swallowing) • stage 2 • steady decline in body function • blindness • loss of speech • coma • prognosis • death within 3 yrs usually • catch in stage 1: can successfully treat with interferon (interventricular) • if stage 2: universally fatal

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