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Proteomics / Metabolomics Breakout Session

Proteomics / Metabolomics Breakout Session. Metabolomics Analyses of M. tuberculosis : unusual lipids and platform/software compatibility – Branch Moody, Brigham and Women's Hospital PARC and Decoy and False Discovery Rates – Chris Becker, PPD, Inc.

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Proteomics / Metabolomics Breakout Session

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  1. Proteomics / Metabolomics Breakout Session • Metabolomics Analyses of M. tuberculosis: unusual lipids and platform/software compatibility – Branch Moody, Brigham and Women's Hospital • PARC and Decoy and False Discovery Rates – Chris Becker, PPD, Inc. • Large Scale Omics and the Requirements for Randomization and Blocking – Charles Ansong, Pacific Northwest National Laboratory • Metabolomics Sample Preparation: Rapid Quenching of Metabolism vs Removal of Sample Matrix – Tom Metz, Pacific Northwest National Laboratory

  2. Discussion Points • Can chromatography be standardized across laboratories? • e.g. standard peptides as retention time locks • Overall peptide scores are not as important as the relative rank of filter passing peptides • Important to block/randomize samples during analysis to avoid confounding of data • Can non-chemical inactivation methods be used? • e.g. gamma irradiation, UV light • Complementary NMR analyses can assist identification of unknown compounds, but requires pure samples • Presence of media constituents can hamper metabolomic/lipidomic analyses • How will transcriptomic, proteomic, and metabolomic data be integrated and used?

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