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PERFORMANCE IN ERNDIM SPECIAL ASSAYS FOR CREATININE DISORDERS

Explore the special assays and schemes for creatinine disorders as detailed in the study by Alberto Burlina & Cas Weykamp. Learn about analytes, methodology, quality assurance principles, and a proposal for modifications to existing assays.

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PERFORMANCE IN ERNDIM SPECIAL ASSAYS FOR CREATININE DISORDERS

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  1. PERFORMANCE IN ERNDIM SPECIAL ASSAYS FOR CREATININE DISORDERS Alberto Burlina & Cas Weykamp

  2. creatinine Clinica Chimica Acta 361 (2005) 1 –9

  3. ERNDIM Special Assay Schemes: Analytes 2007 Urine 5-OH-Indolacetic acid Carnitine free Creatine Creatinine Guanidinoacetate Homovanillic acid Hydroxyproline Lactic acid Mucopolysaccharides Orotic acid Pipecolic acid Sialic acid Succinylacetone Uric acid Serum 3-OH Butyric acid 7-Dehydrocholesterol Aceto acetate C22:0 Behenic acid C24:0 Lignoceric acid C26:0 Cerotic acid Carnitine free Creatine Guanidin acetic acid Galactose Homocysteine Lactic acid Phytanic acid Pipecolic acid Pyruvic acid

  4. S-Guanidinoacetate (17%)

  5. S-Creatine (19%)

  6. U-Creatinine (70%)

  7. U-Creatine (24%)

  8. U-Guanidinoacetate (26%)

  9. Methodology and Quality Assurance in IEM Principles Parameters for method validation(details: ERNDIM web-site, http://www. erndimqa.nl) • Recovery • Range • Linearity Limit of detection Limit of quantitation • Specificity • Selectivity • Precision Repeatability Reproducibility • Accuracy

  10. Special assays serum 2007

  11. Special assays urine 2007

  12. PROPOSAL Special Assays a. Remove of hydroxyproline b. Low level mevalonate c. Low levels carnitine  d. Low levels 3-hydroxybutyrate, urate and creatine

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