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Review of Ingredients Added to Cigarettes Overview Kara Lewis, Ph.D. Staff Scientist

Review of Ingredients Added to Cigarettes Overview Kara Lewis, Ph.D. Staff Scientist. Epidemiology shows that cigarette smoking associates with premature human mortality Effect of added ingredients is unknown. Introduction. A substance other than tobacco that is added to a cigarette.

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Review of Ingredients Added to Cigarettes Overview Kara Lewis, Ph.D. Staff Scientist

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  1. Review of Ingredients Added to Cigarettes Overview Kara Lewis, Ph.D. Staff Scientist

  2. Epidemiology shows that cigarette smoking associates with premature human mortality Effect of added ingredients is unknown Introduction

  3. A substance other than tobacco that is added to a cigarette Definition of Added Ingredient

  4. Assess relative risk of adverse health effects LSRO Approach

  5. Relative Risk Risk (+) ingredient Risk (-) ingredient

  6. LSRO approach Expert Panel Robert Orth, Ph.D. Apis Discoveries, LLC. Resha M. Putzrath, Ph.D., D.A.B.T. (Retired) Georgetown Risk Group Emanuel Rubin, M.D. Department of Pathology, Anatomy, and Cell Biology Thomas Jefferson University James L. Schardein, M.Sc., F.A.T.S. Independent consultant Thomas J. Slaga, Ph.D. AMC Cancer Research Center and Center for Causation and Prevention Carroll E. Cross, M.D. Division of Pulmonary and Critical Care Medicine University of California, School of Medicine Shayne C. Gad, Ph.D., D.A.B.T. Gad Consulting Services Donald E. Gardner, Ph.D., F.A.T.S. Inhalation Toxicology Associates Louis D. Homer, M.D., Ph.D. Holladay Park Medical Center Rudolph J. Jaeger, Ph.D., D.A.B.T. Environmental Medicine, Inc.

  7. Convened 11 times to date Reviewed more than 3000 publications Worldwide literature Clinical studies Government reports Books Received 21 scientific presentations LSRO Approach

  8. Project Structure • Phase I: Determination of Feasibility • Phase II: Development of Scientific Criteria • Phase III: Reviews of Individual Ingredients

  9. Phase I - Feasibility • Determined whether testing ingredients • added to cigarettes is feasible • Reviewed published literature covering • Smoke chemistry and physics • Exposure • Adverse health effects • Issues and methods in testing

  10. Testing is feasible and worthwhile. Publication of the Phase I report is imminent. Phase I - Conclusions

  11. Framework to guide the process of testing ingredients added to cigarettes Phase II – Scientific Criteria

  12. Phase III - Reviews of Individual Ingredients • Use the criteria developed in Phase II • Process: • Literature review • Data analysis

  13. Summary • Compare cigarettes with and without added • ingredients • This approach is feasible • Phase II is underway

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