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Survival (%)

100. 100. REM+SD. A. B. 100. 80. 80. CRP 0h. < 0.5 mg/dL. 80. 60. 60. 100. 100. Survival (%). Survival (%). 55 – 320 ng/mL. LDH 0h. CEA 0h. PD. < 299 U/L. 0.5 – 1.3 mg/dL. 60. 40. 40. Survival (%). censored. 40. 20. 20. 80. 80. < 55 ng/mL. 300 – 393 U/L.

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Survival (%)

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  1. 100 100 REM+SD A B 100 80 80 CRP 0h < 0.5 mg/dL 80 60 60 100 100 Survival (%) Survival (%) 55 – 320 ng/mL LDH 0h CEA 0h PD < 299 U/L 0.5 – 1.3 mg/dL 60 40 40 Survival (%) censored 40 20 20 80 80 < 55 ng/mL 300 – 393 U/L 1.4 - 8.5 mg/dL 20 > 8.5 mg/dL 0 0 0 3 6 9 12 15 18 21 24 0 Time after SIRT (months) 0 3 6 9 12 15 18 21 24 60 60 Time after SIRT (months) C D 100 Survival (%) Survival (%) AST 0h < 35 U/L 321 – 1000 ng/mL 80 394 – 604 U/L 35 – 52 U/L 40 40 60 Survival (%) > 604 U/L 40 53 – 66 U/L 20 20 20 > 66 U/L > 1000 ng/mL 0 0 3 6 9 12 15 18 21 24 Time after SIRT (months) 0 0 E F 100 CA 19-9 0h 0 0 3 3 6 6 9 9 12 12 15 15 18 18 21 21 24 24 11 – 39 U/mL 80 < 11 U/mL Time after SIRT (months) Time after SIRT (months) 60 Survival (%) 40 – 300 U/mL 40 20 > 300 U/mL 0 0 3 6 9 12 15 18 21 24 Time after SIRT (months) G H 100 Nucleosomes 24h 100 CYFRA 21-1 0h < 5 ng/mL 80 < 400 ng/mL 80 752 – 1235 ng/mL 60 5 – 10 ng/mL Survival (%) 60 Survival (%) 400 – 751 ng/mL 40 11 – 33 ng/mL 40 20 > 1235 ng/mL 20 > 33 ng/mL 0 0 3 6 9 12 15 18 21 24 0 Time after SIRT (months) 0 3 6 9 12 15 18 21 24 Time after SIRT (months)

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