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Cancers of the Reproductive System Review Session

Cancers of the Reproductive System Review Session . November 19, 2012. Ashkan Afshin, MD, MPH ScD Candidate, Department of Epidemiology ScD Candidate, Department of Global Health  & Population Harvard School of Public Health Kresge Building, Room 913 677 Huntington Avenue

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Cancers of the Reproductive System Review Session

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  1. Cancers of the Reproductive System Review Session November 19, 2012

  2. Ashkan Afshin, MD, MPH ScD Candidate, Department of Epidemiology ScD Candidate, Department of Global Health & Population Harvard School of Public Health Kresge Building, Room 913 677 Huntington Avenue Boston, Massachusetts 02115 Phone: (949) 235-6137 Email: aafshin@hsph.harvard.edu

  3. Review Sessions • Format: • Q & A (20 min) • Discussing the questions received by email (10 min)

  4. Questions Please send your questions or suggestions to: • Text Message:  (949) 235-6137 • Email: aafshin@hsph.harvard.edu

  5. Midterm Exam

  6. Midterm Exam

  7. Midterm Exam

  8. Stages of Tumor Development A B C E D Weinberg RA. How cancer arises. Sci Am. 1996 Sep;275(3):62-70.

  9. Stages of Tumor Development Weinberg RA. How cancer arises. Sci Am. 1996 Sep;275(3):62-70.

  10. Genetic Abnormalities in Cancer Cells

  11. Genetic Abnormalities in Cancer Cells • Oncogenes • HER2 → Breast Cancer • Tumor Suppressor: • BRCA→ Breast Cancer

  12. New cases of cancer in the US American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society.

  13. New cases of cancer in the US American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society.

  14. New cases of cancer in the US American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society.

  15. True or False? • Testicular cancer is the most common form of cancer in men 16-34 • Positive family history of the testicular cancer increases the risk of the cancer • Testicular cancers is more common in African American males. • Carcinoma in situ can sometimes progress to invasive cancer • Obese men show highest risk of testicular cancer

  16. True or False? • Testicular cancer is the most common form of cancer in men 16-34 • Positive family history of the testicular cancer increases the risk of the cancer • Testicular cancers is more common in African American males. • Carcinoma in situ can sometimes progress to invasive cancer • Obese men show highest risk of testicular cancer

  17. Race & Prostate Cancer Incidence Incidence Mortality Mortality World J Urol (2012) 30:195–200

  18. Race & Prostate Cancer Incidence Incidence Mortality Mortality World J Urol (2012) 30:195–200

  19. Diet & Prostate Cancer Risk Giovannucci et al. Int. J. Cancer: 121, 1571–1578 (2007) Wilson et al. J Natl Cancer Inst. 2011;103(11):876-84. Chan et al. J ClinOncol 23:8152-8160

  20. Diet & Prostate Cancer Risk Giovannucci et al. Int. J. Cancer: 121, 1571–1578 (2007) Wilson et al. J Natl Cancer Inst. 2011;103(11):876-84. Chan et al. J ClinOncol 23:8152-8160

  21. Other Risk Factors for Prostate Cancer

  22. Other Risk Factors for Prostate Cancer

  23. Breast Cancer Risk Factors • True or False? • Nulliparity • Early menarche • Early menopause • Postmenopausal hormone use • Older forms of birth control pills • Premenopausal obesity • Alcohol use

  24. Breast Cancer Risk Factors • True or False? • Nulliparity • Early menarche • Early menopause • Postmenopausal hormone use • Older forms of birth control pills • Premenopausal obesity • Alcohol use

  25. Race/Ethnicity and Breast Cancer American Cancer Society. BreastCancer Facts & Figures 2011-2012. Atlanta: American Cancer Society.

  26. Race/Ethnicity and Breast Cancer American Cancer Society. BreastCancer Facts & Figures 2011-2012. Atlanta: American Cancer Society.

  27. American Cancer Society. Global Cancer Facts & Figures 2nd Edition. Atlanta: American Cancer Society; 2011.

  28. Endometrial Cancer Risk Factors • True or False: • Nulliparity, • Early menarche • Late Menopause • Obesity • Prior breast cancer treatment with tamoxifen • Polycystic ovarian syndrome (PCOS)

  29. Endometrial Cancer Risk Factors • True or False: • Nulliparity, • Early menarche • Late Menopause • Obesity • Prior breast cancer treatment with tamoxifen • Polycystic ovarian syndrome (PCOS)

  30. Obesity • Obesity is not a risk factor for: • Breast Cancer • Ovarian Cancer • Testicular Cancer • Prostate Cancer

  31. Obesity • Obesity is not a risk factor for: • Breast Cancer • Ovarian Cancer • Testicular Cancer • Prostate Cancer

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