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FBW7/CDC4 and Endometrial Cancer

FBW7/CDC4 and Endometrial Cancer. Michael Mastropole. Overview. FBW7/CDC4 is a family of genes Tumor suppressor Directly binds to cyclin E Mutated in about 16% of endometrial cancers. Ubiquitylation. http://upload.wikimedia.org/wikipedia/commons/7/7f/Ubiquitylation.png.

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FBW7/CDC4 and Endometrial Cancer

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  1. FBW7/CDC4 and Endometrial Cancer Michael Mastropole

  2. Overview • FBW7/CDC4 is a family of genes • Tumor suppressor • Directly binds to cyclin E • Mutated in about 16% of endometrial cancers

  3. Ubiquitylation http://upload.wikimedia.org/wikipedia/commons/7/7f/Ubiquitylation.png

  4. The SCF Complex (E3 ligase) Wang et al. 2012

  5. CDC4 targets Cyclin E for Proteolysis Strohmaier et al. 2001

  6. Cyclin E is required for G1/S Transition http://eweb.furman.edu/~wworthen/bio111/4cyclins.jpg

  7. Mouse Model Wang et al. 2012

  8. Endometrial Cancer • Endometrium- lining of the uterus • Typically occurs within a few decades of menopause • 49,560 new cases in 2013

  9. hCDC4 mutations Spruck et al. 2002

  10. Treatments • Surgery • Hysterectomy along with removal of ovaries, fallopian tubes, and lymph nodes • Helps stage the cancer • Chemotherapy • Taxol • Radiation • Potential Treatments • Cdk2 inhibitors www.cancer.org

  11. Prognosis • 1 year survival rate • 92% • 5 year survival rate if cancer has not spread • 95% • 5 year survival rate if cancer has spread • 23% www.nlm.nih.gov

  12. References • http://www.nature.com/nature/journal/v413/n6853/full/413316a0.html • http://cancerres.aacrjournals.org/content/62/16/4535.long • http://www.cancer.org/cancer/endometrialcancer/detailedguide/endometrial-uterine-cancer-treating-by-stage • http://www.nlm.nih.gov/medlineplus/ency/article/000910.htm • http://www.sciencedirect.com/science/article/pii/S0014579312002049

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