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Agenda : Certification Platform: Training - I round Beta testers proposals

XIII PMT meeting – October 24, 2012. Agenda : Certification Platform: Training - I round Beta testers proposals Congress presentations Paper “check for axes”. Platform: Training Phase. 2 Images (Scheltens=0,3). Feedback. Certification set. Feedback. + -.

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Agenda : Certification Platform: Training - I round Beta testers proposals

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  1. XIII PMT meeting – October 24, 2012 • Agenda: • Certification Platform: Training - I round • Beta testers proposals • Congress presentations • Paper “check for axes”

  2. Platform: Training Phase 2 Images (Scheltens=0,3) Feedback Certification set Feedback + - 6 Images (Scheltens=0,1,2,3,4,4) Certification set 10 Images (2 x Scheltens=0,1,2,3,4) Feedback + -

  3. Platform: Training round I https://sodium.crulrg.ulaval.ca/hippocampus/ 10 naives created account 9 naives completed training round 1 5 tracers are planned to complete segmentations by early November 3 tracers are “uncertain” 3 tracers are lacking

  4. Platform: Training round I

  5. Platform: Training round I

  6. Platform: User Account

  7. Platform: Administrator Visibility

  8. Platform: Uploads UCF

  9. Platform: Uploads UCF

  10. Platform: MultiTracer Version

  11. Platform: Parameters

  12. Platform: Discrepancies in segmentation

  13. Platform: Discrepancies in segmentation

  14. Platform: Statistics - Users

  15. Platform: Statistics - Segmentations

  16. Platform: Statistics - Segmentations

  17. Platform: Statistics - Segmentations

  18. Platform: Statistics - Segmentations

  19. Platform: Statistics - Segmentations

  20. Platform: Statistics - Segmentations

  21. Platform

  22. Expansion SOPs Sent to 5 possibly interested companies Proposal by Adam Schwarts Bioclinica also interested to fund cooperatively Will promote to next PPSB meeting (next week) Discussed with Maria Carrillo, she said that the AA may offer a neutral forum through which this could be funded/contracted.

  23. Congress Presentations • CTAD (October, 29-31 2012) • Definition of the Harmonized Protocol for Hippocampal Segmentation • DGPPN Symposium 2012 Berlin (Andreas Fellgiebel, Stefan Teipel) • Segmentation of the hippocampus: Towards a joint EADC-ADNI harmonized protocol • AAN (March 16-23, 2013) • EADC-ADNI Benchmark Images of Harmonized Hippocampal Segmentation • AD/PD (March 6-10, 2013) • Definition of Harmonized Protocol for Hippocampal Segmentation

  24. Papers describing the project Survey of protocols (preliminary phase; published, JAD 2011) Operationalization (preliminary phase; I revision, Alzheimer’s & Dementia, MS n. ADJ-D-12-00094) Axes check short report (Brescia Team, in progress) Delphi consensus (Brescia Team, in progress) Master tracers’ practice and reliability (Brescia Team, in progr) Development of certification platform (Duchesne and coll) Validation data (Brescia Team – companion paper 1) Protocol definition (Brescia Team – companion paper 2) Validation vs pathology (TBD) DONEIN PROGRESSPLANNED

  25. GOLDSTANDARD VALIDATION VS CURRENT PROTOCOLS ASSESSMENT OF SOURCES OF VARIANCE TRAINING SET DEVELOPMENT VALIDATION VS PATHOLOGY 20 naïve tracers 5 master tracers 1 tracer Local Protocol ADNI scans: 2 x 5 Scheltens’s atrophy scores x 2 sides x 2 magnet strengths (1.5-3T) Training ADNI scans: 10 at 1.5T x 2 sides x 7 SUs x 2 tracing rounds Total per rater: 40 hippos QUALIFICATION QUALIFICATION Harmonized Protocol ADNI scans: 2 x 5 Scheltens’s atrophy score x 2 sides x 2 magnet strengths (1.5-3T) Total per rater: 40 hippos Harmonized Protocol ADNI scans: 2 x 5 Scheltens’s atrophy score x 2 sides x 2 magnet strength (1.5-3T) Total per rater: 40 hippos Harmonized Protocol: Pathological datasets: Mayo Clinic and NYU Total: about 40 hippos Assessment of variance due to rater and center REFERENCE PROBABILISTIC MASKS with 95% C.I. Best 5 naïve tracers Assessment of agreement with volume on pathology or ex vivo MRI and correlation with neuronal density Harmonized Protocol ADNI scans: 2 sides x 5 Scheltens’s atrophy scores x 3 time points (bl-1y-2y) x 3 scanners (+ retracing @ bl) x 2 magnet strengths (1.5-3T) Total per rater: 240 hippos Assessment of variance due to side, trace-retrace, atrophy, time, scanner, rater TRAINING SET

  26. GANTT

  27. Publication Policy “ STEERING COMMITTEE (SC) This is made of: (i) the Principal Investigator (P.I.; G.B. Frisoni) (ii) the co-Principal Investigator (co-P.I.; C.R. Jack); (iii) the leader of the Statistical Working Group (S. Duchesne). The SC is chaired by the P.I. and deliberates by majority. ” STANDARD FORM for submission: TITLE of PROPOSAL: PI / CENTRE: AIM of the PROJECT: METHODS of the PROJECT: WHAT IS ASKED to the SC of the HARMONIZED HIPPOCAMPAL PROTOCOL WHAT IS OFFERED to the HARMONIZED HIPPOCAMPAL PROTOCOL PROJECT/COMMUNITY:

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