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Agenda : Validation Harmonized Protocol: update Validation vs pathology

XVIII PMT meeting – June 5, 2013. Agenda : Validation Harmonized Protocol: update Validation vs pathology Hippocampal Label Expansion project: update - News Congress presentations Papers. Validation versus pathology. 1 tracer (Greg). Mony DeLeon 15 AD + 5 CTRL at 1.5T

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Agenda : Validation Harmonized Protocol: update Validation vs pathology

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  1. XVIII PMT meeting – June 5, 2013 • Agenda: • Validation Harmonized Protocol: update • Validation vs pathology • Hippocampal Label Expansion project: update • - News • Congress presentations • Papers

  2. Validation versus pathology 1 tracer (Greg) Mony DeLeon 15 AD + 5 CTRL at 1.5T postmortem MRI and quantitative histology (possible additional AD cases) (Bobinsky paper on 9 AD+4 NL sbj scanned with Philips) Mayo Clinic AD + CTRL + MCI dataset with pathologically confirmed diagnosis (Braak’s stages), but not postmortem hippocampal measurement 15 Philips + 18 GE 13 post-mortem 10 post-m T1 PD 50 antem Segmentation based on Harmonized Protocol: Analysis based on the information available for each dataset and vs Bobinsky’s paper

  3. de Leon GE PD

  4. Partial volume??

  5. de Leon Philips T1

  6. Hippocampal Label Expansion project: update Subjects = 135 Hippocampi = 270 MRI tracer tracing QC/correction Certification 68/68 1.5 T Masami Complete I-II Complete (67 3T) 30/30 Dominik Complete I-II Complete 12/12 Rossana Complete I-II Complete 10/10 Martina Complete I-II Complete 15/15 Michel Complete I-II Complete

  7. Hippocampal Label Expansion project: SD update • SD received all of the certified labels • Tracers are Masters or platform-Qualified. Anyway, exact ICCs across the 5 can be computed using the volumes of the Qualification round. • PLATFORM • SD has tech support from PAVI, at Université de Sherbrooke • They are looking into file formats for the contours • - SD has scheduled a meeting with the Technical Advisory group

  8. News: Subfields Group composed by Paul Yushkevich, Susan Mueller and Lei Wang aims to converge hippo-subfields imagers for protocol harmonization. They asked for our participation, to tune the protocols and import harmonizaton methods. We are invited to present the Hippo Harmonization project a-remoto to their HS3 meeting, June 21-2 http://hippos3.wordpress.com/

  9. News: Duvernoy Duvernoy explained some unclear anatomy issues and approved: AC-PC standard orientation Inclusion of “vestigial” tissue Choices of the Delphi panel Participation as a coauthor

  10. Congress Presentations • NEXT HARMONIZATION MEETING: JULY 17 H 12-14 • AIC-AAIC (Boston, July 13-18, 2013) • Training of Naïve Tracers; Statistics for Certification Platform POSTERS • - AIC-AAIC developing topics • Validation phase 1: preliminary data; Expansion project: preliminary data on 1.5T images • SUBMITTED • CTAD (San Diego, Nov 3-5, 2011) • Validation phase 1: preliminary data; Expansion project: preliminary data on 1.5T imagesSUBMITTED

  11. Papers • Survey of protocols (preliminary phase; JAD 2011) • Operationalization (preliminary phase; Alzheimer’s & Dementia, published online) • Axes check short report (Brescia Team, ADJ-D-13-00030, I revision) • Master tracers’ practice and reliability (Brescia Team, Sent to coauthors) • Development of certification platform (Duchesne and coll) • Consensual Protocol definition (Brescia Team – companion paper 1) • Validation data (Brescia Team – companion paper 2) • Validation vs pathology (TBD) DONEONGOINGPLANNED

  12. GOLDSTANDARD VALIDATION VS CURRENT PROTOCOLS ASSESSMENT OF SOURCES OF VARIANCE TRAINING SET DEVELOPMENT VALIDATION VS PATHOLOGY 20 naïve tracers 5 master tracers 1 tracer Local Protocol ADNI scans: 2 x 5 Scheltens’s atrophy scores x 2 sides x 2 magnet strengths (1.5-3T) Training ADNI scans: 10 at 1.5T x 2 sides x 7 SUs x 2 tracing rounds Total per rater: 40 hippos QUALIFICATION QUALIFICATION Harmonized Protocol ADNI scans: 2 x 5 Scheltens’s atrophy score x 2 sides x 2 magnet strengths (1.5-3T) Total per rater: 40 hippos Harmonized Protocol ADNI scans: 2 x 5 Scheltens’s atrophy score x 2 sides x 2 magnet strength (1.5-3T) Total per rater: 40 hippos Harmonized Protocol: Pathological datasets: Mayo Clinic and NYU Total: about 40 hippos Assessment of variance due to rater and center REFERENCE PROBABILISTIC MASKS with 95% C.I. Best 5 naïve tracers Assessment of agreement with volume on pathology or ex vivo MRI and correlation with neuronal density Harmonized Protocol ADNI scans: 2 sides x 5 Scheltens’s atrophy scores x 3 time points (bl-1y-2y) x 3 scanners (+ retracing @ bl) x 2 magnet strengths (1.5-3T) Total per rater: 240 hippos Assessment of variance due to side, trace-retrace, atrophy, time, scanner, rater TRAINING SET

  13. GANTT

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