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ACYLATION

ACYLATION. L.O.: What is an acylation reaction? What is the nucleophilic addition-elimination mechanism fro acylation reactions?. The acyl group:. Acylation is the process by which the acyl group is introduced into another molecule.

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ACYLATION

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  1. ACYLATION L.O.: What is an acylation reaction? What is the nucleophilic addition-elimination mechanism fro acylation reactions?

  2. The acyl group: Acylation is the process by which the acyl group is introduced into another molecule.

  3. Think of examples of types of compounds containing the acyl group.

  4. water + propanoyl chloride

  5. ammonia + ethanoyl chloride 

  6. propan-2-ol + ethanoyl chloride 

  7. ethylamine + propanoic anhydride 

  8. propylamine + butanoyl chloride 

  9. propan-1-ol + ethanoic anhydride 

  10. water + butanoic anhydride 

  11. ammonia + propanoic anhydride 

  12. Addition-elimination mechanism

  13. Addition-elimination mechanism

  14. Name and outline the mechanism for the reaction between propanoyl chloride and methylamine.

  15. Advantages of using ethanoic anhydride over ethanoyl chloride as an acylating agent: Cheaper Less corrosive It does not react with water as readily Safer. By-product is ethanoic acid rather than HCl.

  16. ASPIRIN

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