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What is phylogeography?How do we do it?Examples (if time). . Phylogeography. What is phylogeography?A field of study concerned with the principles and processes governing the geographic distribution of genealogical lineages, especially those within and among closely related speciesAvise 2000

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Plant of the day

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    1. Plant of the day

    2. What is phylogeography? How do we do it? Examples (if time)

    3. What is phylogeography? A field of study concerned with the principles and processes governing the geographic distribution of genealogical lineages, especially those within and among closely related species Avise 2000

    4. Phylogeography uses principles from population genetics and phylogenetics However… Does not assume an equilibrium between drift and gene flow Does not assume non reticulation Historical relationships and gene flow influence spatial patterns of genetic variation

    5. Historical relationships and contemporary gene flow influence spatial patterns of genetic variation Similarity due to gene flow Similarity due to historical relationships

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    7. Why do we care? Phylogeographic methods provide a means of examining the history of genetic exchange among populations, with the potential to distinguish biogeographic patterns of genetic variation caused by gene flow from those caused by common ancestry (Schaal 1998). We can tease apart contemporary forces of genetic exchange from historical relationships

    8. How do we do it? Phylogeography makes use of coalescent theory Is a statistical framework for the analysis of genetic polymorphism data Is an extension of classical population genetics theory It is used to estimate time (number of generations) since lineages coalesced Many applications

    9. We go backwards in time from the present Lineages can randomly “pick” their parents as we go back in time (no selection) When two lineages pick the same parent they coalesce All lineages will eventually coalesce to the MRCA of the sample The rate that lineages coalesce depends on the number of lineages (more lineages the faster the rate) and the size of the population (the more parents to pick from, the slower the rate) Recombination, gene flow and selection can be incorporated into the model

    10. Classical population genetics -based on allele frequencies -alleles are either the same or different, no degrees of similarity Phylogeography -based on gene genealogies -both the frequencies of sequence haplotypes and their relationship is considered Coalescent Theory -a mathematical approach to solving population genetic problems explicitly considers genealogical processes, even if the data are allele frequencies

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    12. Descriptive phylogeography Plot haplotypes on map Classify pattern of phylogeographic structure Consider historical explanations Look for concordance among different species (comparative phylogeography)

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    20. Nested clade analysis … is a [coalescent based] method of statistical phylogeographic inference that tests hypotheses about the association of clades (branches) of haplotype trees with spatial information. (Templeton, 2010)

    22. Con NCA -Lack of statistical rigor: “NCA does not assess error in its inferences about historical processes or contemporary gene flow” (Knowles and Maddison 2002) -Just because a process tends to cause a particular geographic pattern does not mean that other processes could have caused it -Incorrect historical processes were inferred by NCA in 75% of the simulated datasets (Panchal and Beaumont 2007) -Phylogenies assumed to be without error

    23. Pro NCA -first attempt to provide a method of statistical inference for phylogeography -the alternative involves computer simulations of complex phylogeographic scenarios with multiple parameters (Templeton 2010) -alternative methods require predetermined hypothesis about the demographic history of populations

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