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Development of CD8 + T cells in the thymus

Development of CD8 + T cells in the thymus. THYMUS. Death by Neglect due to Weak signalling. Cortical epithelial cell. Medullary epithelial cell Or Dendritic cell. Lymphoid progenitor. Positive selection. CD8 committed T cell. CD8 T cell. TO THE PERIPHERY!. Negative selection

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Development of CD8 + T cells in the thymus

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  1. Development of CD8+ T cells in the thymus THYMUS Death by Neglect due to Weak signalling Cortical epithelial cell Medullary epithelial cell Or Dendritic cell Lymphoid progenitor Positive selection CD8 committed T cell CD8 T cell TO THE PERIPHERY! Negative selection and death Double negative T cell Double positive T cell CD4 committed T cell MEDULLA CORTEX Raine Toivonen

  2. Activation of CD8+ T cells in the periphery • CD8+ T cell encounters an activated APC • The APC presents antigen on its surface within MHC I • Antigens can be bound to MHC I either when they are synthesized within the cell (endogenous or viral antigens) or transferred from phagosomes to cytosolic compartment (cross-presentation of exogenous antigens) • CD8 T cell produces IL-2 to drive its own proliferation CD8+ T CELL Dendritic cell IL2R CD8 TCR MHC I Ag CD80 / CD86 CD28 IL2R IL-2 Raine Toivonen

  3. The DC is activated by CD4+ T cell: license to kill CD8+ T CELL DENDRITIC CELL CD4+ T HELPER CELL IL12R CD40 CD40L TCR Ag MHC I TCR Ag CD8 CD4 B7 (CD80 / CD86) CD28 CD28 Raine Toivonen

  4. Killing mechanisms • Perforin/Granzymes CTL Infected cell DNA CASPASE Ag Raine Toivonen

  5. Killing mechanisms 2. FAS / FAS ligand Infected cell CTL DAXX RIP1 FADD RAIDD CASPASE 2 DISC ASK1 ProCASPASE 8 CASPASE 8 Ag CASPASE 3 JNK APOPTOSIS Raine Toivonen

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