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DIVISION OF BIOMEDICAL SCIENCES

DIVISION OF BIOMEDICAL SCIENCES. Fundamental Research. Transformative Results . Strategies for Early Stage Investigators National Institutes of Health June 2009 Dr. Lizanne DeStefano I-STEM Education Initiative University of Illinois at Urbana-Champaign. 1110 Micro & Nanotechnology Lab

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DIVISION OF BIOMEDICAL SCIENCES

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  1. DIVISION OF BIOMEDICAL SCIENCES Fundamental Research. Transformative Results. Strategies forEarly Stage Investigators National Institutes of Health June 2009 Dr. Lizanne DeStefano I-STEM Education InitiativeUniversity of Illinois at Urbana-Champaign 1110 Micro & Nanotechnology Lab 208 N. Wright Street Urbana,IL 61801 217.244.8480 biomedical@illinois.edu

  2. Successful NIH Grant Writing June 24, 2009 GRANT ROLE & STATUS • • K Awards • Mentored or Independent Scientist • • R (R03, R21, R01) Awards • - Principal Investigator • - Bolster Project Expertise & Experience with: • • Co-Investigators - budgeted • • Other Significant Collaborators - not budgeted • • External Advisory Board – stipends • - Possibility of Multiple PIs DIVISION OF BIOMEDICAL SCIENCES

  3. Successful NIH Grant Writing June 24, 2009 NIH FUNDING FOR EXTRAMURAL RESEARCH • • Career Development Opportunities: • Mentored Research (pre & post-doc, new faculty) • Transition to Independent Research • • Ongoing Research Opportunities: • Investigator-Initiated Research, Unsolicited • Program Announcement (PA), Solicited • • One-Time Research Opportunities: • Request for Applications (RFA), Solicited • Request for Proposals (RFP), Solicited DIVISION OF BIOMEDICAL SCIENCES

  4. Successful NIH Grant Writing June 24, 2009 ENTRY-LEVEL K (CAREER) AWARDS DIVISION OF BIOMEDICAL SCIENCES

  5. Successful NIH Grant Writing June 24, 2009 ENTRY-LEVEL RESEARCH CAREER AWARDS • • K01: Mentored Research Scientist • • K08: Mentored Clinical Scientist • • K23: Mentored Patient-Oriented Research Career • • K25: (since 2000) Mentored Quantitative Research • - Quantitative science and engineering • • K99: (since 2008) NIH Pathways to Independence: • Includes Mentored + Independent Research • Up to 3 Yrs to successful R01. DIVISION OF BIOMEDICAL SCIENCES

  6. March 19, 2009 Successful NIH Grant Writing June 24, 2009 NUMBER OF ENTRY LEVEL RESEARCH CAREER AWARDS Number of Awards Fiscal Year DIVISION OF BIOMEDICAL SCIENCES

  7. March 19, 2009 Successful NIH Grant Writing June 24, 2009 SELECT RESEARCH CAREER DEVELOPMENT AWARDS: APPLICATIONS, AWARDS, & SUCCESS RATES DIVISION OF BIOMEDICAL SCIENCES

  8. March 19, 2009 Successful NIH Grant Writing June 24, 2009 K-AWARD FUNDING • Mentored Awards (K01, K08, K23, K25): • Salary: .50 FTE minimum • Research Development: • Tuition & fees, research expenses, meeting & training travel, statistical • K22 Career Transition (post-doc to faculty) • Salary: .75 FTE minimum, up to $100K/yr + fringe • Research Expenses: Up to $50K per year • K99 Pathways: 1-2 yrs post-doc + up to 3 yrs independent research DIVISION OF BIOMEDICAL SCIENCES

  9. March 19, 2009 Successful NIH Grant Writing June 24, 2009 PURSUING A K AWARD • • Seek information from • - NIH Office of Extramural Research • • Seek advice from • - Mentors with existing NIH track records • - NIH Institute Personnel DIVISION OF BIOMEDICAL SCIENCES

  10. March 19, 2009 Successful NIH Grant Writing June 24, 2009 RESEARCH GRANTS: INITIATING AN UNSOLICITED SUBMISSION Identify specific NIH Research Area & Program Write one-page sketch Contact Program Officer with one-pager: discuss ideas, assess fit with program goals DIVISION OF BIOMEDICAL SCIENCES

  11. March 19, 2009 Successful NIH Grant Writing June 24, 2009 RESEARCH GRANTS: PROGRAM ANNOUNCEMENTS (PA) • Solicit applications in given research area • New, ongoing or expanded interest &/or high-priority program • 3-5 year fundingperiods • Standardized yearly cycle (receipt, peer review, council review, & start) • Available until PA expires • Most common form of NIH grant competition DIVISION OF BIOMEDICAL SCIENCES

  12. March 19, 2009 Successful NIH Grant Writing June 24, 2009 RESEARCH MECHANISMS: R03 Small Research Grant (R03) • • $50K in direct costs each year for two years • - Project can be carried out in a short period with limited resources • • Pilot or feasibility studies • • Secondary analysis of existing data • •Development of research methodology and/or technology DIVISION OF BIOMEDICAL SCIENCES

  13. March 19, 2009 Successful NIH Grant Writing June 24, 2009 RESEARCH MECHANISMS: R21 Exploratory/Developmental Research Grant (R21/R33) • • $250K in Direct Costs over 3 Years • - Innovation & novelty • Pilot-scale support for potentially ground-breaking ideas & methods. • Lacks preliminary data to document feasibility • - Major impact on biomedical research if successful DIVISION OF BIOMEDICAL SCIENCES

  14. March 19, 2009 Successful NIH Grant Writing June 24, 2009 RESEARCH MECHANISMS: R01 Research Project Grant (R01) • • No set $ cap or duration, • • Size thresholds – consult announcement & program officer! • - Discrete project in investigator's area • - Documented preliminary data required • - Largest NIH funding category DIVISION OF BIOMEDICAL SCIENCES

  15. March 19, 2009 Successful NIH Grant Writing June 24, 2009 ALLOCATIONS OF R01 GRANTS (FY2003) Awards Made: • 82% for investigator-initiated research grants • 10% for Program Announcements • 8% for RFAs For more information on funding rates >> DIVISION OF BIOMEDICAL SCIENCES

  16. March 19, 2009 Successful NIH Grant Writing June 24, 2009 PUBLISHED DATES: UNSOLICITED & PROGRAM ANNOUNCEMENTS DIVISION OF BIOMEDICAL SCIENCES

  17. March 19, 2009 Successful NIH Grant Writing June 24, 2009 MORE INFORMATION ON THE NIH CYCLE DIVISION OF BIOMEDICAL SCIENCES

  18. March 19, 2009 Successful NIH Grant Writing June 24, 2009 NEW & EARLY STAGE INVESTIGATOR POLICIES • • New Investigator: • - No Previous NIH R01 research grant funding • - No negative effect on status if have: • •Small Grant (R03) • •Exploratory, Developmental Research Grant (R21) • •Loan repayment programs • •Fellowships DIVISION OF BIOMEDICAL SCIENCES

  19. March 19, 2009 Successful NIH Grant Writing June 24, 2009 EARLY STAGE INVESTIGATOR (ESI) • • An ESI is a New Investigator with • - Terminal research degree within past 10 years • - Not yet awarded substantial, competing NIH research grant  • • How does NIH recognize ESIs? • NIH eRA Commons profile data: degree conferral and medical • residency dates • -Be VERY selective about sharing your eRA Commons login! DIVISION OF BIOMEDICAL SCIENCES

  20. March 19, 2009 Successful NIH Grant Writing June 24, 2009 NIH COMMITMENT TO NEW & EARLY STAGE INVESTIGATORS • • Special consideration during peer review & at time of funding • - Accelerated feedback schedule • - Early opportunities to resubmit • • Peer reviewer instructions: • - Focus more on proposed approach than on track record • - Expect less preliminary data than from established investigator DIVISION OF BIOMEDICAL SCIENCES

  21. March 19, 2009 Successful NIH Grant Writing June 24, 2009 DEFINED, SPECIFIC RESEARCH PURPOSE • Specific project goals • Articulate limited set of hypotheses • Plans for analysis: tie to stated research hypotheses or questions DIVISION OF BIOMEDICAL SCIENCES

  22. March 19, 2009 Successful NIH Grant Writing June 24, 2009 COMPETITIVE PROJECT DESIGN • Limit size & scale (manageability) • Provide concrete project design • Document instrument validity • Assign specific roles to project personnel • Provide realistic time & activity sequences • Plan for revisions & changes needed while project is underway DIVISION OF BIOMEDICAL SCIENCES

  23. March 19, 2009 Successful NIH Grant Writing June 24, 2009 BUDGET DESIGN • • What do you NEED to do the work? • • Support all research narrative activities • • University budget: Work with business staff • - Adjust totals to award limits • - Meet funder requirements • - Meet University requirements DIVISION OF BIOMEDICAL SCIENCES

  24. March 19, 2009 Successful NIH Grant Writing June 24, 2009 SUBMIT… AND RESUBMIT • • Submission Outcomes • - Anticipate peer reviewer feedback • - Respond to all specific points • - Build on experience and previous submissions • • Resubmissions: As of 1/25/2009, limited to ONCE! DIVISION OF BIOMEDICAL SCIENCES

  25. June 24, 2009 Grants Homework Determine grant mechanism and institute for submission Find a relevant funding opportunity and review application guidelines Write specific aims (1-page limit) Include name and contact information Save file as: LAST NAME_Award Type-Institute 6. Submit to kuzmuk@illinois.edu by 12:00 noon on Monday, July 6th DIVISION OF BIOMEDICAL SCIENCES

  26. March 19, 2009 Successful NIH Grant Writing June 24, 2009 PREPARING SPECIFIC AIMS • After reading the specific aims, a reviewer should be able to answer the • following questions: • What is your hypothesis? (Is it focused?) • How will you test your hypothesis? (Are your approaches reasonable & appropriate?) • Why is the work important to the mission of NIH? • What makes your ideas/approach/talents unique? • Detailed tutorial on preparing an application >> DIVISION OF BIOMEDICAL SCIENCES

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