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Single- and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals

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Single- and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals

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    1. Single- and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals

    2. Conflict of Interest Disclosure

    3. What is “heritability”?

    5. Will studying gene expression help solve the mystery?

    6. Outline

    7. Icelandic Family Blood (IFB) cohort

    8. Icelandic Family Adipose (IFA) cohort

    9. IFB and IFA cohorts

    10. Identity-by-descent (IBD) estimates

    11. Outline

    12. Heritability of gene expression in IFB, IFA

    13. Heritability of gene expression in IFB, IFA

    15. h2 = 0.15-0.23 is consistent with previous results

    16. Outline

    17. cis vs. trans heritability in IFB, IFA

    18. cis vs. trans heritability in IFB, IFA

    19. cis vs. trans heritability in IFB, IFA

    20. cis vs. trans heritability in IFB, IFA

    21. Systematic noise covariance hinders estimation of h2

    22. No systematic noise covariance in estimation of hcis2

    23. cis vs. trans heritability in IFB, IFA

    24. Is pcis= 24-37% consistent with previous results?

    25. Is pcis= 24-37% consistent with previous results?

    26. Is pcis= 24-37% consistent with previous results?

    27. Is pcis= 24-37% consistent with previous results?

    28. The epigenetic hypothesis

    29. The epigenetic hypothesis

    30. Similar hcis2 using IBD in unrelated individuals

    31. Is pcis= 24-37% consistent with previous results?

    32. Outline

    33. Gene expression is correlated across tissues

    34. Cross-tissue heritability in IFB, IFA

    35. Cross-tissue heritability in IFB, IFA

    36. Cross-tissue heritability in IFB, IFA

    37. Cross-tissue heritability in IFB, IFA

    38. Tissue-specific cis-regulation is consistent with previous studies

    39. Is pcis= 24-37% consistent with previous results?

    40. Cell-type specific cis-regulation could explain tissue-dependent pcis

    41. Conclusions

    42. Conclusions

    43. Conclusions

    44. Conclusions

    45. Acknowledgements

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