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Human Endocrine Physiology

Human Endocrine Physiology. February 27, 2014. Sex Determination and Differentiation. SRY. SRY. AMH T. SRY Gene. Testicular Steroid Pathways. LH/FSH. Cholesterol. Pregnenolone. 17OH-Preg. Progesterone. 17OH-Prog. A4. T. Conversion of Testosterone to Dihydrotestosterone. SRY.

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Human Endocrine Physiology

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  1. Human Endocrine Physiology February 27, 2014

  2. Sex Determinationand Differentiation

  3. SRY

  4. SRY AMH T

  5. SRY Gene

  6. Testicular Steroid Pathways LH/FSH Cholesterol Pregnenolone 17OH-Preg Progesterone 17OH-Prog A4 T

  7. Conversion of Testosteroneto Dihydrotestosterone

  8. SRY AMH T

  9. Conversion of Testosteroneto Dihydrotestosterone

  10. Adrenal Steroid Pathways ACTH Cholesterol Pregnenolone 17OH-Preg DHEA Progesterone 17OH-Prog Androstenedione Testosterone Cortisol Aldosterone

  11. Classical Congenital Adrenal Hyperplasia ACTH Cholesterol Pregnenolone 17OH-Preg DHEA Progesterone 17OH-Prog Androstenedione * * Testosterone Cortisol Aldosterone *21-hydroxylase loss of function mutation

  12. Classical Congenital Adrenal Hyperplasia ACTH Cholesterol Pregnenolone 17OH-Preg DHEA Progesterone 17OH-Prog Androstenedione * * Testosterone Cortisol Aldosterone *21-hydroxylase loss of function mutation

  13. Human Endocrine Physiology:The Menstrual Cycle

  14. Ovarian Physiology GnRH Pituitary LH FSH Inhibin Estrogens Ovary Progesterone Androgens

  15. Gonadotropin Releasing Hormone (GnRH) (hypothalamus) + (pituitary) Sex steroid Inhibin* - (+) LH FSH + (ovary) *Inhibin exerts negative feedback only at the pituitary and only on FSH

  16. Insulin

  17. Ovarian Steroid Pathways LH/FSH Cholesterol Pregnenolone 17OH-Preg Progesterone 17OH-Prog A4 Estrone Estradiol T

  18. * * *Only enzyme to know

  19. Changes in HormonesAcross the Menstrual Cycle FSH 0 Ov 30

  20. Changes in HormonesAcross the Menstrual Cycle Estradiol 0 Ov 30

  21. Changes in HormonesAcross the Menstrual Cycle LH 0 Ov 30

  22. Changes in HormonesAcross the Menstrual Cycle Progesterone 0 Ov 30

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