By Matthew Morgan, Andrew Lomanto , Taylor Stauffer

1. Cystic Fibrosis By Matthew Morgan, Andrew Lomanto, Taylor Stauffer http://www.kiwifamilies.co.nz/Topics/Support+Groups/Illness/Cystic+Fibrosis.html

2. A hereditary disorder • Makes glands secrete a sticky mucus which clods the pancreas, liver, and intestines . • Infection of the lungs What is Cystic Fibrosis http://www.nlm.nih.gov/medlineplus/ency/imagepages/18135.htm

3. Both parents can carry the gene • Occurs right after birth • Child has 25% chance of getting Cystic Fibrosis if both parents are heterozygous carriers and 50% of being a carrier • Abnormal recessive gene • Both parents need to be carriers in order for the off spring to inherit Cystic Fibrosis Cystic Fibrosis Inheritance

4. Cystic Fibrosis Inheritance Punnet Square http://www.csupomona.edu/~biology/bio110/inherit/genes.html

5. 1/25 of all Caucasians carry this disease Cystic Fibrosis Frequency http://www.greatstrides.com.au/images/nebulisertreatment.jpg http://breathe4tomorrow.org/wp-content/uploads/2008/12/alexus.jpg

6. Very salty skin • Frequent coughing • Wheezing • Impaired growth (due to lack of nutrition) • Greasy feces Symptoms Effects • -Because of sticky mucus, the pancreas is clogged, which impairs digestive enzyme flow to intestines, which minimizes the patient, potential to digest food and harvest nutrients • Sticky mucus also creates a layer around the lungs makes it harder for patient to breath, especially during cardio activates • Average life expectancy of persons with Cystic Fibrosis: about 30 years Symptoms and Effects http://www.exposay.com/weeman-the-world-premiere-of-jackass-number-two/p/4630/65/

7. Usually discovered in early childhood • Simple procedure, where the patient is tested for excessive levels of sodium chloride in their sweat How is it Diagnosed? http://www.baynews9.com/article/news/2011/january/192524/New-hope-for-people-living-with-cystic-fibrosis

8. It is possible to extract the pancreas, to overcome the lack of digestive enzyme flow • Daily back slapping is in order, because it helps break up the mucus. • Gene Therapy- It is possible to inject a normal, healthier gene into the patient. This therapy has had high hopes from scientists, but has shown no positive results yet. • Currently, there are a few known antibiotics that have proven to increase one’s life expectancy How is this Disease Treated?

9. There is no known cure, but scientists everywhere are striving to produce one for this disease. There is a foundation for this disease, which raises money for aid to the current patients, and for finding a cure in the near future Is There a Cure?

10. A type of gene therapy, which takes advantage of the need to remove introns. This makes a functional mrna, so genes will continue to reduce possibility of the patient’s child getting the disease SMaRT Therapy

11. “About Cystic Fibrosis.” Cystic Fibrosis Foundation. Cystic Fibrosis Foundation, n.d. Web. 28 Jan. 2011. <http://www.cff.org//>. • “Cystic Fibrosis.” Encyclopedia of Genetics. Ed. Don P. Dawson. Vol. 1. Pasadena, CA: Salem Press Inc., 2004. 195-198. Print. • “Cystic Fibrosis.” Genetic Science Learning Center. Learn Genetics , 28 Jan. 2011. Web. 28 Jan. 2011. <http://learn.genetics.utah.edu/////ex.html>. • Jacoby, David R., and Robert M. Youngson. “Cystic Fibrosis.” Encyclopedia of Famliy Health. Ed. Joyce Tavolacci. Vol. 4. Tarrytown, NY: Marshall Cavendish, 2005. 448. Print. • “What is Cystic Fibrosis.” TOBI. TOBI, 2011. Web. 28 Jan. 2011. <http://www.tobitime.com///‌cystic_fibrosis.jsp?utm_medium=cpc&utm _content=about+cystic+fibrosis&utm_source=MSN&utm_campaign=Tob i_Unbr anded_2.25.10>. Works Consulted