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Neoadjuvant Chemotherapy vs. Radiotherapy in Cervical Cancer

This randomized phase III study compares neoadjuvant chemotherapy followed by surgery with concomitant radiotherapy and chemotherapy for FIGO stage IIB cervical cancer. The primary endpoint is overall survival, with secondary endpoints including progression-free survival and quality of life.

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Neoadjuvant Chemotherapy vs. Radiotherapy in Cervical Cancer

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  1. Randomized phase III study of neoadjuvant chemotherapy followed by surgery vs concomitant radiotherapy and chemotherapy in FIGO stage IIB cervical cancer • Study coordinators: Dr F. Landoni Dr G.Kenter Dr S.Greggi Dr. Colombo A. • Number of randomized patients required: 686 EORTC 55994

  2. Eligibility criteria

  3. 55994Endpoints Primary endpoint: overall survival Secondary endpoints: progression free survival quality of life

  4. 55994Stratification factors • Institution • FIGO stage • Performance status

  5. 55994Treatment scheme

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