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結構生物學 期末報告

結構生物學 期末報告. 指導老師 鄒文雄 學生 林彥君. 從蛋白結構看 arabidopsis tubby-like protein2 的 F-box domain 和 ASK1 蛋白，形成 SCF complxe 的可能性. Skp1&F-box in SCF. http://au.expasy.org/tools/blast/. > Tlp2Fbox SPWASLPPELLHDIIWRVEESTAWPARAAVVSCASVCKSWRGITMEIVRIPEQCG. http://au.expasy.org/tools/blast/.

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結構生物學 期末報告

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  1. 結構生物學 期末報告 指導老師 鄒文雄 學生 林彥君

  2. 從蛋白結構看arabidopsis tubby-like protein2的F-box domain和ASK1 蛋白，形成SCF complxe的可能性

  3. Skp1&F-box in SCF

  4. http://au.expasy.org/tools/blast/ >Tlp2Fbox SPWASLPPELLHDIIWRVEESTAWPARAAVVSCASVCKSWRGITMEIVRIPEQCG

  5. http://au.expasy.org/tools/blast/ >ASK1(arabidopsis) MASVGIAPNPGARDSTGVDKLPEEMNDMKIRDDKEMEATVVDGNGTETGHIIVTTIGGRNGQPKQTISYM AERVVGHGSFGVVFQAKCLETGETVAIKKVLQDRRYKNRELQTMRLLDHPNVVSLKHCFFSTTEKDELYL NLVLEYVPETVHRVIKHYNKLNQRMPLIYVKLYTYQIFRALSYIHRCIGVCHRDIKPQNLLVNPHTHQVK LCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDVWSAGCVLAELLLGQPLFPGESGVDQLV EIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRSAALDTLVH PFFDELRDPNARLPNGRFLPPLFNFKPHELKGVPLEMVAKLVPEHARKQCPWLGL

  6. No 1LDK

  7. Cul1-Rbx1-Skp1-F Boxskp2 SCF Ubiquitin Ligase Complex • PDB ID:1LDK • Source:Homo sapiens • Deposition Date:08-Apr-2002 • Classification:Ligase

  8. SCF complex (1LDK)

  9. 模擬ASK1在SCF complex中的位置

  10. 模擬ASK1立體結構

  11. 模擬F-box在SCF complex中的位置

  12. 模擬F-box立體結構

  13. ASK1&F-box in SCF complex

  14. ASK1 F-box

  15. Conclusion • Mutant arabidopsis tubby-like protein2 (P52L) of F-box resulted in reduction of the interacting activity with ASK1(C.L Lee, 2004)

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