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A Brief Cynical History of Pharmacology

A Brief Cynical History of Pharmacology. PROBLEM "I have an earache" SOLUTION 2000 BC- Here, eat this root 1000 AD- That root is heathen, say this prayer 1850 AD- That prayer is superstition, drink this potion 1940 AD- That potion is snake oil, swallow this pill

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A Brief Cynical History of Pharmacology

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  1. A Brief Cynical History of Pharmacology PROBLEM • "I have an earache" SOLUTION • 2000 BC- Here, eat this root • 1000 AD- That root is heathen, say this prayer • 1850 AD- That prayer is superstition, drink this potion • 1940 AD- That potion is snake oil, swallow this pill • 1985 AD- That pill is ineffective, take this antibiotic • 2000 AD- That antibiotic is artificial , here eat this root

  2. Paracelsus Paracelsus (11 November or 17 December 1493 in Einsiedeln, Switzerland - 24 September 1541) was an alchemist, physician, astrologer, and general occultist. Born Phillip von Hohenheim, he later took up the name Philippus Theophrastus Aureolus Bombastus von Hohenheim, and still later took the title Paracelsus, meaning "equal to or greater than Celsus", a Roman physician from the first century BC.

  3. Paracelsus: Genius with bad press agent • Attended Universities of Heidelberg, Freiburg, Ingolstadt, Cologne, Tübingen, Vienna, Erfurt and Ferrara, left without degree, drank to excess, and wandered over most of known world, took part in Peasants War (1525) • Practiced medicine in Spain, Portugal, England, Denmark, Poland, Prussia, Hungary, Arabia, Egypt, Turkey, probably other places as well • Pioneered use of chemicals, elements in medicine (Zn, Hg, Au) • Introduced draining to replace amputation or cauterization • Introduced dose-response concept • Recognized first industrial disease

  4. Paracelsus • Alle Ding' sind Gift und nichts ohn' Gift; allein die Dosis macht, dass ein Ding kein Gift ist. ("All things are poison and nothing is without poison, only the dose permits something not to be poisonous.”)

  5. Paracelsus: a few weird facts • “Paracelsus” (1943 film by Georg Wilhelm Pabst) • Professor Bulwer in 1922 Murnau film 'Nosferatu' is a follower of Paracelsus • “Paracelsus” (lengthy dramatic poem by Robert Browning) • “Paracelsus and The Rose” (short story by Borges) • Paracelsus is one of the people featured on a Chocolate Frog card in Harry Potter. A bust of Paracelsus is in the castle at Hogwarts, near Gryffindor, between the entrance to the Gryffindor common room and the Owlry, as mentioned in Order of the Phoenix • In “The Phantom” comic strip, Paracelsus appeared in “The Ring”. According to this story, Paracelsus gave the first Phantom the Skull Ring

  6. Some Pharmacologists in History • William Withering, 1741-1799 (digitalis) • Claude Bernard 1813-1878 (d-tubo curare) • Friedrich Sertürner 1783--1841 (morphine) • Rudolf Buchheim 1820-1879 (1st Pharmacology Laboratory, University of Dorpat (now Tartu, Estonia) • Oswald Schmiedeberg 1838-1921 (Strassburg, now Strasbourg, trained many pharmacologists) • John Langley 1852--1926 (Receptor concept) • Paul Ehrlich 1854-1915 (Receptor concept) • Otto Loewi, Henry Dale (Neurotransmission)

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