1 / 17

NOYORI

noyori mechanism briefly explained. i did it in a hurry, credits will be later updated in description. hope this slide will help u. thanks!

zuzu
Download Presentation

NOYORI

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Aida SurayaAzzuhri 2010663418 Nor Zulfa bintiTahir 2009713131 NurhafizahMohdSalleh 2009925855 NOYORI ORGANOMETALLIC CHEMISTRY CHM676 PROF DR HADARIAH

  2. INTRODUCTION BIOGRAPHICAL OF RYOJI NOYORI

  3. NOYORI CATALYSTS

  4. MECHANISM

  5. EXAMPLE:

  6. NOYORI ASYMMETRIC HYDROGENATION chemical reaction that adds two atoms of hydrogen to a target (substrate) molecule with three dimensional spatial selectivity. ASSYMETRIC HYDROGENATION characterized by asymmetry in the spatial arrangement or placement of parts or components. ASYMMETRICAL ? THEREFORE NOYORI ASSYMETRIC HYDROGENATION chemical reaction for the enantioselective hydrogenation of ketone, aldehydes, and imines.

  7. NOYORI CATALYSTS

  8. MECHANISM

  9. APPLICATION Noyori asymmetric hydrogenation. • Chemical reaction for the enantioselective hydrogenation of ketones, aldehydes and imines. • BINAP-Ru catalyst – functionalized ketones. • BINAP/diamine-Ru catalyst – simple ketones. • Used in production of several drugs, such as the antibacterial levofloxin, the antibiotic carbapenem and the antipsychotic agent BMS181100.

  10. Industrial application • An antibacterial levofloxacin is synthesized using (R)-1,2-propandiol, which is synthesized from hydroxyacteone using Noyori asymmetric hydrogenation(Takasago Co./Daiichi Pharmaceutical Co.).

  11. An antibiotic carbapenem is also prepared using Noyori asymmetric hydrogenation via (2S,3R)-methyl 2-(benzamidomethyl)-3-hydroxybutanoate, which is synthesized from racemic methyl 2-(benzamidomethyl)-3-oxobutanoate by dynamic kinetic resolution.

  12. An antipsychotic agent BMS 181100 is synthesized using BINAP/diamine-Ru catalyst.

  13. REFERENCES • http://www.chem.harvard.edu/groups/myers/handouts/22_Noyori_Asymmetric_Hydrog.pdf • http://www.synarchive.com/named-reactions/Noyori_Asymmetric_Hydrogenation

  14. RYOJI NOYORI

More Related