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Recovery of Organic Acids From Fermentation Broths Southern Bio-Products Conference March 4-6, 2004 Beau Rivage Resort B

Recovery of Organic Acids From Fermentation Broths Southern Bio-Products Conference March 4-6, 2004 Beau Rivage Resort Biloxi, MS Tim Eggeman, Ph.D., P.E. Dan Verser, Ph.D. ZeaChem Inc. Organic Acids - Today. Points of View. Sugars: Inexpensive Under-Utilized More Sustainable

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Recovery of Organic Acids From Fermentation Broths Southern Bio-Products Conference March 4-6, 2004 Beau Rivage Resort B

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  1. Recovery of Organic Acids From Fermentation Broths Southern Bio-Products Conference March 4-6, 2004 Beau Rivage Resort Biloxi, MS Tim Eggeman, Ph.D., P.E. Dan Verser, Ph.D. ZeaChem Inc.

  2. Organic Acids - Today

  3. Points of View • Sugars: • Inexpensive • Under-Utilized • More Sustainable • Synthetic Routes will Eventually be Displaced • Platform Viewpoint is Under-Utilized Biology plus = Better Technology and Chemistry Market Diversification

  4. Generic Platform

  5. C2 Platform

  6. Issues in Recovery • pH of Broth • Unreactive Species at Near Neutral pH • Commodity Scale Production is Constrained by Need to Avoid Salt Coproduction • Dilute Broths • Evaporating Water is Expensive • Prefer Selective Methods for Removing Organic Acids from Water

  7. Effect of pH

  8. pH Options • Low pH Fermentation • Neutral pH Fermentation • Direct Acidification • Amine Complex Formation • Other • Bipolar Electrodialysis • Esterases

  9. Lactic Acid - Traditional Alcohol Water Hydrolysis Sulfuric Acid Ester Lime Lactic Acid Direct Acidification Fermentation Esterification Sugars Water Gypsum

  10. Direct Acidification US Demand for Lactic Acid = 176 MM lb/yr, Gypsum Coproduct = 252 MM lb/yr !!!

  11. Lactic Acid – Amine Extraction (From: Baniel, A.M. et. al., US Pat. 5,510,526)

  12. Citric Acid – Lime/Acid Lime Sugars Fermentation Precipitation Residue Sulfuric Acid Water Calcium Citrate Acidification Crystallization Citric Acid Gypsum

  13. Citric Acid – Amine Extraction Water Forward Extraction Water Back Extraction Sugars Fermentation Crystallization Citric Acid Residue

  14. Formic Acid Water Formic Acid CO Carbonylation Methyl Formate Hydrolysis Methanol Methanol

  15. Some Common Themes • Eliminating Salt Coproduction is Difficult • Microbiology • Careful Selection of Cations and Recovery Scheme • Common Purification Methods • Amine Extraction • Esterification

  16. Routes to Ethanol

  17. Lab Status - Fermentation • Lab Scale Fermentation • Strain: Moorella Thermoacetica ATCC 39073 • Media: Glucose+Corn Steep Liquor • Batch Results • First Run: 28 g/l acetate • Goal: 35-50 g/l acetate, yield = 85+% of theoretical

  18. Lab Status - Recovery • Lab Scale • Amine Complex Formation w/ CaCO3 Precipitation • Extraction of Amine Complex • Esterification • Results to Date • 97+% CaCO3 Recovery • Excellent Extraction (KD > 2) • Ester Yield: 75% of Theoretical

  19. Conclusions • Technical Issues • pH and Avoidance of Salt Coproduction • Dilute Broths • Advantages of Platform Viewpoint • New Routes Based on Biology and Chemistry • Market Diversification

  20. Acknowledgements • US Department of Energy - Inventions and Innovation Program (Grant Number DE-FG36-03GO13010) • Support by US DOE Does Not Constitute an Endorsement by US DOE of the Views Expressed in this Presentation

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