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J. Fűrész

CONTROLLING DANGEROUS PATHOGENS PROJECT Regional Workshop on Dual-Use Research Mátraháza , Hungary May 12-14, 2006. J. Fűrész. Nobel prize winner Hungarian s. O = élettani ill. orvosi, F = fizikai, K = kémiai, B = béke, G = közgazdasági dí.

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J. Fűrész

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  1. CONTROLLING DANGEROUS PATHOGENS PROJECT Regional Workshop on Dual-Use Research Mátraháza, Hungary May 12-14, 2006 J. Fűrész

  2. Nobel prize winner Hungarians O = élettani ill. orvosi, F = fizikai, K = kémiai, B = béke, G = közgazdasági dí

  3. „CONTROLLING DANGEROUS PATHOGENS PROJECT”1999 Study Rapid detection of security related bioagents Preparation a laboratory capability to enhance the protection of human resources Multipurpose, modular, deployable, mission tailorable,,,

  4. Bio security in its broad meaning, can be seen as active measures to avoid spread of human &/or agricultural pathogens Bio-safety can be seen as the protection of the workers of the laboratories and installations, as well as the protection against the uncontrolled/unwilling spread of pathogens or diseases to the outside.

  5. The menace has to be encountered in regional context. • It makes unavoidable sharing information and experience on preparedness, response plans and crisis management strategies in regional approach.

  6. We are focusing on health threats, want to strengthen mechanisms and capacities to identify, to verify and to respond to threats. We are aware and know the requirements for diagnostic needs and means of surveillance and epidemiological activities

  7. MULTINATIONAL CHEMICAL, BIOLOGICAL, RADIOLOGICAL, AND NUCLEAR TASK FORCE, CHALKIDA, GreeceAug01-Oct01

  8. Do we initiate a knowledge harmonization process at regional level (?)!

  9. Janus-facedScienceDual-Use Research J. Fűrész

  10. The modern science and technology has a driving role in the development and there is a need to strengthen economic, technical and scientific co-operation Science was the engine of progress of Western civilization over the last three centuries. Religio, religare = relation, community in common mind. In the recent century appeared a new pseudo-religion: the science

  11. What relatively easy to do: Specification of Weaponization-related goals.

  12. 1.   Enhance pathogen infectivity, pathogenicity, antibiotic resistance, or resistance to host immunological defenses • Improve the ability of a microbial pathogen to remain viable and virulent during prolonged storage and/or after release into the environment • Facilitate the dissemination of biological agents as a fine-particle aerosol • Facilitate the dissemination of a biological agent by contamination of food or water sources • Create a novel pathogen or one with characteristics that have been altered to evade current detection methods or host immune defenses • Assemble oligonucleotides to synthesize the genome of a pathogenic microorganism.

  13. The Dual Use Dilemma (I) • Dual use research means science, with legitimate purpose • that may be misused to pose public health and/or national security

  14. The Dual Use Dilemma (II) Microbiology just a part of the landscape • Deliberate engineering of immune escape, stealth viral vectors • Overproduction of host inflammatory mediators to produce toxic shock • Knocking out genes that regulate key cell processes such as cell proliferation. • Small molecules that disrupt molecular circuits, eg networks in immune response, blood clotting system, higher brain function • Acoustic disruption – bone pain, airway modulation, ultrasonic skin heating. George Poste, NAS meeting 2003 (not formally published):

  15. Advances in life sciences & biotechnology bring benefits to medicine, public health, & agriculture. Risk to public safety and security from the misuse of this science & technology . Naturally occurring accidents Misadventure Deliberate misuse

  16. Dual use research in life sciences includes research: • with legitimate scientific purpose • that may be misused to pose a biologic threat to public health and/or national security

  17. Weak understanding of the implications of dual-use capabilities posed by research in the life sciences

  18. What to do ? The special character of the science.

  19. The knowledge acquisition is a result of personal activity, the community of scientist characterized by the autonomy. The scientist itself is not a machine looking for the truth, but the scientist has full autonomy to accept or reject the verity of anything. Autonomy of Science Polányi (1929) a tudósközösség autonómiáját, a tudás személyes és hallgatólagos aspektusát hangsúlyozza, de távol tartja magát azoktól a nézetektõl is, amelyek már a tudásszociológia elõfeltevéseit jelentik: társadalomba-ágyazottság, közöstudat, stb. A tudás megszerzése személyes aktus eredménye. Nem szociologizálja, mindemellett kimondja, hogy a tudós nem valamiféle igazságkeresõ gép, hanem "végsõ soron a tudós maga dönti el, hogy mit fogad el igazságként".(Faragó Péter:TUDOMÁNYTERVEZÉS ÉS TUDOMÁNYOS AUTONÓMIA. http://66.249.93.104/search?q=cache:jnoSV-4cj-QJ:www.kfki.hu/chemonet/polanyi/0012/farago.html+k%C3%B6z%C3%B6s+tudat+tudom%C3%A1ny&hl=hu&gl=hu&ct=clnk&cd=1&client=firefox-a) Polányi Mihály

  20. Universality of Science • freedom of movement, • association, • expression and communication for scientists as well as • equitable access to data, information and research materials

  21. The publication of results is expected from scientific community, which resulted in the appearance of new kind of collective thinking With the rise of ubiquitous networked communication due to the internet and its enhancement by mobile access anytime, anywhere, our capacities for effective problem- solving both on the practical and the more abstract levels have vastly increased. The misuse of the impersonalized knowledge increased

  22. What & how to do (I)? Have to develop effective national and international laws, regulations, and policies in relation to the life sciences

  23. What & how to do (II)? • Have to develop a culture of responsibility of • Scientists, • Management of laboratories, • Industry and research facilities • Governmental & non-governmental institutions employing and funding research in the life sciences. • Publishers • Educational and training system

  24. What do not do? Do not prohibit research of any kind that is carried out with peaceful intent, or restrict the publication of results.

  25. Where we are now ?

  26. We are all on the same shipboard. DON’T MISS, DON’TLEAK THE BOAT

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