Oleoylethanolamide(OEA): A Weight Loss Drug That Helps To Control Appetite

1. www.wisepowder.com wise12@wisepowder.com Oleoylethanolamide(OEA): A Weight Loss Drug That Helps To Control Appetite 1 / 16

2. www.wisepowder.com wise12@wisepowder.com What Is Oleoylethanolamide (OEA)? Oleoylethanolamide (OEA) is a natural regulator of weight, cholesterol, and appetite. The metabolite is synthesized in small quantities in the small intestines. The natural molecule is responsible for the feeling of fullness after you take food. Oleoylethanolamide assists in regulation of body fat by binding to Peroxisome proliferator-activated receptor alpha (PPAR-Alpha). This natural metabolite enhances body fat metabolism and informs your brain that you’ve taken enough food and you should stop eating. Oleoylethanolamide also increases non-workout related calorie expenditure. How Does Oleoylethanolamide (OEA) Work? Oleoylethanolamide (OEA) Mechanism of action Oleoylethanolamide (OEA) functions as an appetite regulator. Oleoylethanolamide controls your food intake by sending signals to the brain informing it that you’re full, and it’s time to stop eating. As a result, you take less food on a daily basis, and your body stops packing more weight in the long term. Oleoylethanolamide (OEA ) (111-58-0) is produced and mobilized in the small intestine from oleic acid derived from the diet. Food with high fat content can inhibit production of Oleoylethanolamide in the proximal small intestine. 2 / 16

3. www.wisepowder.com wise12@wisepowder.com Oleoylethanolamide lowers food intake by stimulating histamine brain circuitry, homeostatic oxytocin, and hedonic dopamine pathways. It is evident that Oleoylethanolamide can also attenuate CB1R signaling, which if stimulated may lead to increased food intake. Oleoylethanolamide decreases lipid transport into adipocytes to lower fat mass. OEA also functions to stimulate something known as PPAR and simultaneously lowers fat storage and increases burning of fat. Whenever you take a meal, the levels of OEA rises and your appetite falls. This happens because the sensory nerves linked to your brain inform it that you are full thanks to the PPAR-α. PPAR-α is a ligand-activated nuclear receptor which is involved in energy homeostasis pathways and gene expression of lipid metabolism. Oleoylethanolamide (OEA) showcases all characteristics that defines satiety factor which include:  Inhibiting feeding by increasing the time interval between one meal to the next meal;  Its production is controlled by availability of nutrients  Its levels undergo circadian fluctuations. 3 / 16

4. www.wisepowder.com wise12@wisepowder.com Oleoylethanolamide (OEA) Benefits Oleoylethanolamide benefits and weight loss effects includes; i. Reducing appetite stimulating hormone known as Ghrelin 4 / 16

5. www.wisepowder.com wise12@wisepowder.com Peripheral injections of OEA administered to rodents which had been fasting for one day didn’t influence ghrelin hormone within 120 minutes, but after 6 hours there was a remarkable decrease in this hormone by 40 to 50 percent. However, Oleoylethanolamide had no effects on the concentrations of this appetite stimulating hormone in fed rodents. This suggests that OEA supplement works best in reducing ghrelin levels if taken before meals. ii. Increasing the rate of body fat loss The βeta-adrenergic receptors works to stimulate body weight loss and stimulation of the βeta3-adrenergic receptor elicits a decrease in food intake and increased fat loss in rats. The receptor does so by stimulating uncoupling proteins including UCP1. As a result, co-administration of β3 agonist and oleoylethanolamide peripheral injection seem to be effective in decreasing food intake and efficient in lowering fat mass associated with a rise in expenditure of energy. The rise in the levels of UCP1 and PPARα (thought to reflect energy expenditure rise) occurred in both brown and white adipose tissue alongside enhancements in mitochondrial biomarkers. OEA therefore appears to enhance the mitochondrial metabolism effects and thermogenic actions in rodents in both brown and white adipose tissues, at the same oleoylethanolamide dosage as that used to control appetite. iii. Lowering The Level of Peptide YY (Appetite-Stimulating Hormone) Injections of 5mg/kg Oleoylethanolamide to rodents caused time-dependent decrease in hormone peptide YY which is produced in the gut in both the fed and food-deprived state. 5 / 16

6. www.wisepowder.com wise12@wisepowder.com Does Oleoylethanolamide (OEA) Help Control Appetite? Yes. Oleoylethanolamide weight loss supplement helps to control appetite by activating PPAR thereby decreasing storage of fat and increasing burning of fats. When you take your meals, Oleoylethanolamide levels rises and your appetite lowers when signals are sent to your brain informing the brain that you are satisfied. There have been several scientific studies that prove this effect. In 2004, for instance, Danish researchers studied mice that had been deprived food for one day. They gave them OEA and realized that the amount of food they took decreased by 15.5%. In simpler terms, Oleoylethanolamide (OEA) turns off the switch for hunger in the C.N.S. (Central Nervous System). Oleoylethanolamide (OEA) Dosage The recommended oleoylethanolamide dosage is one capsule 200mg when taken without any combination. When combined with other weight loss supplements, OEA dose should be lowered to between 100mg and 150mg. It is suggested that you take oleoylethanolamide supplement 30 minutes prior to dinner or breakfast; you’ll feel more satisfied during your meal time and end up taking less food. Research suggests that you can also lower or increase daily dosage according to your bodyweight. For instance, if you weigh 150lb, you may take 100mg. A 200lb person may take 150mg and a 250lb person may take 180mg of the supplement. 6 / 16

7. www.wisepowder.com wise12@wisepowder.com Oleoylethanolamide (OEA) Side Effects 7 / 16

8. www.wisepowder.com wise12@wisepowder.com Oleoylethanolamide side effects can be a major concern among supplement manufacturers who want to include this powerful ingredient in their supplement’s weight loss formula. After an in-depth review of all the available scientific data, the U.S. FDA (Food and Drug Administration) had no issues concerning the safety of this natural molecule. RiduZone was the first OEA powder to be branded in 2015. OEA is an oleic acid metabolite and part of a healthy daily meal. It is completely safe to take Oleoylethanolamide supplement since there is no serious side effects have been so far reported. Oleoylethanolamide (OEA) Buy You can get an oleoylethanolamide buy from several online and physical drug stores. You’ll however need to be cautious since not all suppliers are genuine. Make sure that you read their oleoylethanolamide reviews to know what the experience of their previous buyers was. Are you wondering on where to get oleoylethanolamide for sale? Don’t worry; you can buy oleoylethanolamide online here on our website. We are a reputable and experienced OEA supplier and we have the ability to deliver Oleoylethanolamide (OEA) in USA and several other countries around the world. Our order process is simple but completely secure and safe. We also deliver our products in tightly sealed and elegant packages to ensure safety and avoid any contamination. 8 / 16

9. www.wisepowder.com wise12@wisepowder.com 9 / 16

10. www.wisepowder.com wise12@wisepowder.com 10 / 16

11. www.wisepowder.com wise12@wisepowder.com 11 / 16

12. www.wisepowder.com wise12@wisepowder.com 12 / 16

13. www.wisepowder.com wise12@wisepowder.com 13 / 16

14. www.wisepowder.com wise12@wisepowder.com 14 / 16

15. www.wisepowder.com wise12@wisepowder.com Article by: Dr. Liang Co-founder, the company’s core administration leadership; PhD received from Fudan University in organic chemistry. More than nine years of experience in organic synthesis field of medicinal chemistry. Rich experience in combinatorial chemistry, medicinal chemistry and custom synthesis and project management. References:  Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. The Journal of the American Medical Association. 2006; 295(7):761–775.  Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). “Postprandial increase of oleoylethanolamine mobilization in small intestine of the Burmese python (Python molurus)”. Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407–R1412.  Sarro-Ramirez A, Sanchez-Lopez D, Tejeda-Padron A, Frias C, Zaldivar-Rae J, Murillo-Rodriguez E. Brain molecules and appetite: the case of oleoylethanolamide. Central Nervous System Agents in Medicinal Chemistry. 2013;13(1):88–91. 15 / 16

16. www.wisepowder.com wise12@wisepowder.com  Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C (2006). “Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents”. Cell Metab. 3 (3): 167–175. 16 / 16