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Design of a facility to host experiment mice in space

Design of a facility to host experiment mice in space. MDS. Mice Drawer System. Gabriele Baronio, Giancarlo Falcetti, Stefano Uberti, Valerio Villa. Device to host a colony of 6 mice in space (on board of ISS). Available commercial space (“ rack ”) with given interfaces.

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Design of a facility to host experiment mice in space

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  1. Design of a facilityto host experiment micein space MDS Mice Drawer System Gabriele Baronio, Giancarlo Falcetti, Stefano Uberti, Valerio Villa

  2. Device to host a colony of 6 mice in space (on board of ISS). • Available commercial space (“rack”)with given interfaces. • Functions: to feed, to water, administer controlled dosages of drugs, remove excrements, environmental conditioning. • 6 separate cages without contacts between mice. • Needs: guarantee mice’s physic and psychic well-being to have realistic results in experiments. MDS

  3. Design targets Box: 440.1x253.2x516.1 [mm] 12mm insulation, only on lateral walls. Max dimensions Animals contained 6 Mice 30-40 days/mouse 90 day between launch and landing Permanence in space Switch on/off, Led, Data connector, Power connector, Air in filter, Air out filter, Water refilling connector, Food refilling opening Rack Panel connection

  4. Needs Dimensions 6 cages + den max available surface Vmin=650 cm^3/mouse Air Filters in/out + Pump + Manifold + Vent-hole Reservoir (2-3l) + Pump + pipes Consumption: 20-30% mouse’s weight/day Water Food Food tablet Dry food x 100 days 3 Kg LHU (Liquid Handling Unit) Drug reservoir + Electrovalves + Metering pump

  5. Bacteriological in & out Biological/microbiological Environment control Food reminder and excrements removing Cleaning Filters Decease management ? Temperature Heat exchanger Climatic control Humidity Desiccator Insulation Filters Management and Control Electronic unit Mobile camera camera + guide + motor

  6. Electronic unit Biological/micro-biological Insulation Heat exchanger Water and food Available space Up/Down Lateral walls with insulation Materials Containers Rack panel

  7. Breadboard

  8. Cages study

  9. MDS Cages details

  10. Mouse’s habitat

  11. Final cage + Food handling

  12. Simple “Sandwich” type assembling

  13. Experiment container

  14. Liquid handling

  15. LHULiquid Handling Unit

  16. Drugs and water handling

  17. LHU can be distributed as we need, because it is pipe-connected and not rigid

  18. Comparison between hypothesis Building elements

  19. Breadboard building

  20. ... thank you

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