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CSX

Day 62. CSX. Day 0. CSX. BGN. BGN. 3.1% 2. 0% 1. 0% 1. 0% 1. 3.1% 2. 0% 1. 0% 1. 0% 1. 7.8% 3. 3.1% 2. 0% 1. 0% 1. 6.3% 3. 6.3% 2. 0% 1. 1.4% 2. 17.2% 3. 9.4% 3. 0% 1. 6.9% 2. 4.7% 3. 21.9% 5. 11.1% 1. 11.1% 3. 28.1% 3. 9.4% 2. 5’ to 3’

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CSX

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  1. Day 62 CSX Day 0 CSX BGN BGN 3.1% 2 0% 1 0% 1 0% 1 3.1% 2 0% 1 0% 1 0% 1 7.8% 3 3.1% 2 0% 1 0% 1 6.3% 3 6.3% 2 0% 1 1.4% 2 17.2% 3 9.4% 3 0% 1 6.9% 2 4.7% 3 21.9% 5 11.1% 1 11.1% 3 28.1% 3 9.4% 2 5’ to 3’ order of methylation 30.6% 4 29.7% 5 14.1% 4 16.7% 3 one crypt, eight tags 44.4% 1 56.3% 3 42.2% 3 62.5% 4 Summary Parameter (averages) Day 0 Day 62 p value* CSX Methylation 19.3% 9.9% 0.21 BGN Methylation 10.8% 12.3% 0.87 CSX Unique Tags/Crypt 3.22 2.33 0.09 BGN Unique Tags/Crypt 1.38 2.12 0.19 (*Two-sided t-test)

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