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PROSPER: trial design

PROSPER: trial design. Shepherd J et al. Lancet. 2002;360:1623-30. Placebo. Pravastatin. Age (yrs). 75.3. 75.4. Female (%). 52. 52. History of any vascular disease, n (%). 1259 (43.2). 1306 (45.2). Current smoker, n (%). 805 (27.6). 753 (26.0). History of hypertension, n (%).

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PROSPER: trial design

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  1. PROSPER: trial design Shepherd J et al. Lancet. 2002;360:1623-30

  2. Placebo Pravastatin Age (yrs) 75.3 75.4 Female (%) 52 52 History of any vascular disease, n (%) 1259 (43.2) 1306 (45.2) Current smoker, n (%) 805 (27.6) 753 (26.0) History of hypertension, n (%) 1793 (61.6) 1799 (62.2) Mean SBP/DBP (mm Hg) 154.6/83.94 154.7/83.64 History of diabetes, n (%) 320 (11.0) 303 (10.5) PROSPER: Baseline Clinical Characteristics Shepherd J et al. Lancet. 2002;360:1623-30

  3. Placebo Pravastatin Total cholesterol (mg/dL) 221 221 HDL-C (mg/dL) 50 50 LDL-C (mg/dL) 147 147 Triglycerides (mg/dL) 133 133 PROSPER: Baseline Lipid Profile Shepherd J et al. Lancet. 2002;360:1623-30

  4. PROSPER: primary endpoint (coronary death, nonfatal MI, and stroke). Shepherd J et al. Lancet. 2002;360:1623-30

  5. PROSPER: rates of CHD-related death and nonfatal MI Shepherd J et al. Lancet. 2002;360:1623-30

  6. PROSPER: rate of CHD-related death Shepherd J et al. Lancet. 2002;360:1623-30

  7. PROSPER: rates of fatal and nonfatal stroke Shepherd J et al. Lancet. 2002;360:1623-30

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