Ligand Design

Since firstly described in 2001, PROTACu00ae has been developed to be a promising and widely applied technology for drug discovery. Generally, a PROTACu00ae is a class of heterobifunctional molecules composed of a target ligand and an E3 ligase ligand connected by an optimal linker. Different from conventional enzyme inhibitors, the PROTACu00ae usually functions by targeting degradation of various proteins, extensively including nuclear receptors, kinases, regulators proteins, fusion proteins, and so forth.<br><br>https://www.creative-biolabs.com/protac/ligand-design-for-ahr-targeting-protac.htm

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