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Insulin Resistance

Insulin Resistance. Progression to Diabetes. Hypertension: BP >140/90 Dyslipidemia : TG >150 mg/ dL (1.7 mmol.L ) HDL-C <35 mg/ dL (0.9 mmol /L) Obesity (central): BMI >30 kg/M2 Waist girth > 94 cm (37 inch) Waist/Hip ratio > 0.9 Impaired Glucose Handling: IR, IGT or DM

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Insulin Resistance

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  1. Insulin Resistance Progression to Diabetes

  2. Hypertension: BP >140/90 • Dyslipidemia: • TG >150 mg/dL (1.7 mmol.L) • HDL-C <35 mg/dL (0.9 mmol/L) • Obesity (central): BMI >30 kg/M2 • Waist girth > 94 cm (37 inch) • Waist/Hip ratio > 0.9 • Impaired Glucose Handling: IR, IGT or DM • FPG >110 mg/dL (6.1 mmol/L) • 2 hr. PG >200 mg/dL (11.1 mmol/L)

  3. Inflammation

  4. Stage 1 – Early Insulin Resistance

  5. Treatment recommendations for Stage 1 Stage 1 – Early Insulin Resistance

  6. Graph represents patient's stage of pre-diabetes. Stage 2 – Elevated Insulin

  7. Treatment recommendations for stage 2

  8. Graph represents patient's stage of pre-diabetes. Stage 3: Beta-Cell Dysfunction

  9. Treatment recommendations for stage 3

  10. High hs-CRP associated with: • Chronic inflammatory state. • Insulin resistance (independent of obesity) and increased risk of type 2 diabetes. • Hypertension, metabolic syndrome, and aging. • Increased risk of coronary artery disease, peripheral artery disease, and increased risk of cardiac death in individuals with previous heart attack. Inflammation MarkersHigh-sensitivity C-Reactive Protein (hs-CRP)

  11. Treatment Options to reduce hs- CRP:

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