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Design Matrix Diffusion-Controlled Systems

Design Matrix Diffusion-Controlled Systems

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Design Matrix Diffusion-Controlled Systems

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  1. Design Matrix Diffusion-Controlled Systems In a matrix diffusion-controlled system, the drug is bound to a polymeric carrier in a dispersed form. For controlled release systems using non- biodegradable polymeric materials as carriers, the solubility of the drug in the system is the controlling factor for the release rate. For biodegradable polymers, the release rate is controlled both by the solubility of the drug in the system and by the rate of degradation of the polymeric carrier. Matrix System Types Homogeneous Matrix Systems In a homogeneous matrix system, the drug is dissolved or dispersed in a homogeneous matrix, primarily a polymer. Once the matrix system is immersed in the dissolution medium, the drug present on the surface of the matrix will dissolve in the dissolution medium. This will result in concentration differences and the drug will diffuse from the inner to the outer layers of the matrix. As a result, a depletion zone will form at the boundary of the matrix

  2. and will increase over time. The release rate will also decrease over time as the drug must diffuse over longer distances. Porous matrix systems Porous matrix systems are a variant of homogeneous matrix systems. In this case, the drug is dissolved in a porous polymer. Once the matrix system is immersed in the dissolution medium, the pores will be filled with the dissolution medium and the drug will be dissolved in the filled pores of the matrix. In addition to the solubility and diffusion coefficient of the drug in the release medium, the shape and volume of the pores in the matrix are also important. Performance Testing of Matrix Diffusion-Control System Before the tests are performed, the drug, polymer and other substances need to be made into polymer films, which are then subjected to a series of performance characterization tests. •FTIR spectroscopy, which is used to detect any physical and chemical interactions between the polymer and the drug. •SEM testing, which can be used to observe the surface morphology of the patch before and after drug release. •XRD testing, which is used to confirm the physicochemical properties of the drug in the polymer matrix of the transdermal patch.

  3. •DSC testing, which is used to confirm the identity and purity of the drug. •In vitro release studies, used to assess the effect of the polymeric mixture on the release of the drug from the matrix patch. Source: https://www.formulationbio.com/design-services-for-matrix-diffusion-controlled- systems.html

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