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Protein Synthesis and Protein Folding

Protein Synthesis and Protein Folding. Remember proteins?. What are their monomers? Amino Acids – 20 to choose from Where are they synthesized in the cell? Ribosomes (poke your ribs!) What are some functions of proteins? Antibodies, Enzymes, Muscle fibers, growth, storage. Amino Acids.

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Protein Synthesis and Protein Folding

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  1. Protein Synthesis and Protein Folding

  2. Remember proteins? • What are their monomers? • Amino Acids – 20 to choose from • Where are they synthesized in the cell? • Ribosomes (poke your ribs!) • What are some functions of proteins? • Antibodies, Enzymes, Muscle fibers, growth, storage

  3. Amino Acids

  4. How do the amino acids know their order? • DNA (***common genetic code!!!) codes for proteins • DNA uses sequences of 3 bases called codons to tell the ribosome what amino acid comes next • DNA – its your instructions!

  5. Proteins and their function • In order for proteins to be able to function they must be folded correctly (we say have the correct conformation) • 4 levels of protein folding

  6. Levels of Protein folding • Primary – a strand of amino acids

  7. Levels of Protein folding • Secondary – amino acid chain doubles back on itself linked by H bonds • Alpha (α) helix or Beta (β) pleated sheet

  8. Levels of Protein folding • Tertiary - α helix and βsheets fold onto themselves to make a 3D structure. • This is the final structure of some proteins

  9. Level of protein folding • Quaternary – several tertiary proteins bonded together • Working form of most proteins

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