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Epub March 5, 2 012 annals

Epub March 5, 2 012 www.annals.org. Guideline Panel Members. Magda Barini-García , MD - Health Resources and Services Administration Vanessa Elharrar , MD, MPH - National Institute of Allergy and Infectious Diseases Tia Morton, RN, MS - National Institute of Allergy and Infectious Diseases

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Epub March 5, 2 012 annals

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  1. Epub March 5, 2012www.annals.org

  2. Guideline Panel Members MagdaBarini-García, MD - Health Resources and Services Administration Vanessa Elharrar, MD, MPH - National Institute of Allergy and Infectious Diseases Tia Morton, RN, MS - National Institute of Allergy and Infectious Diseases Charles Holmes, MD, MPH - Office of the Global AIDS Coordinator ShoshanaKahana, PhD - National Institute on Drug Abuse Peter Kilmarx, MD - Centers for Disease Control and Prevention Cynthia Lyles, PhD - Centers for Disease Control and Prevention Henry Masur, MD - National Institutes of Health Celso Ramos, MD, MSc - Federal University of Rio de Janeiro Evelyn Tomaszewski, MSW - National Association of Social Workers Marco Antônio de Ávila Vitória, MD - World Health Organization

  3. External Reviewers American Academy of HIV Medicine - Donna E Sweet, MD Association of Nurses in AIDS Care - Robert T. Carroll, MN, RN British HIV Association - Jane Anderson, PhD & John Walsh, MBBS European HIV Nurses Network - Ann Deschamps, RN, MSN Donna Futterman, MD Brian Gazzard, MD, MA HIV Medicine Association (HIVMA) Physician Assistant AIDS Network - Carl Stein, MHS, PA-C

  4. Acknowledgements Funding was provided by the US National Institutes of Health, Office of AIDS Research and IAPAC IAPAC: Jose Zuniga, PhD; Angela Knudson Cindy Lyles, PhD: CDC Prevention Research Synthesis database Systematic reviews: Laura Bernard, MD, Kathryn Mussig MD, Jennifer Johnsen, MD Editorial assistance: Anne McDonough

  5. “Antiretroviral therapy (ART) is recommended and should be offered to all persons regardless of CD4 cell count.”

  6. Rationale • NO BRAINER #1: NoCARE= no ART • NO BRAINER #2: Successful ART requires RETENTION in care • NO BRAINER #3: High ADHERENCE is required for maximal and durable individual and public health benefit

  7. Methods • Systematic review of the international literature since 1996 • Keyword searches of CDC’s Prevention Research Synthesis database of over 46,000 citations; ad hoc and hand searches of key literature; and conference abstracts from last 2 years produced over 300 studies • Qualifying studies had to have a comparator arm • Interventions had to have been studied in context of HIV • Evidence reviewed by 2 independent reviewers using modified Newcastle-Ottawa and Cochrane criteria • Writing Team graded quality of body of evidence and strength of recommendations

  8. Methods: Monitoring • Keyword searches specific to adherence measurement or monitoring • Qualifying studies had to include at least one adherence measurement method and have a biologic or clinical outcome • Two independent reviewers abstracted data using Quality Assessment for Diagnostic Accuracy Studies (QUADAS) tool

  9. Quality of the Body of Evidence and Strength of Recommendations

  10. Guideline Structure • Monitoring • Interventions • Entry Into and Retention in Care • ART Strategies • Adherence Tools • Education and Counseling • Health Service and Service Delivery

  11. Guideline Structure • Special Populations • Pregnant Women • Children and Adolescents • Persons with Substance Use Disorders • Persons with Mental Health Disorders • Incarcerated Populations • Homeless and Marginally Housed Persons • Emerging Issues • Recommendations for Future Research

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