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Blood Clotting Pathway

Blood Clotting Pathway. Prothrombin Thrombin. Vitamin K. Adds γ COO- to glutamate of prothrombin. Also VII IX X. Coumadin Inhibits vit K action. Thrombin (hydrolysis at arginine-glycine). 3. A α B β γ. 2. Fibrinogen. Fibrino peptide 2A+2B.

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Blood Clotting Pathway

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  1. Blood Clotting Pathway

  2. Prothrombin Thrombin Vitamin K Adds γCOO- to glutamate of prothrombin Also VII IX X Coumadin Inhibits vit K action

  3. Thrombin (hydrolysis at arginine-glycine) 3. Aα Bβ γ 2 Fibrinogen Fibrino peptide 2A+2B 2α, β, γ monomers (aggregate) Fibrin Thrombin – homologous to trypsin

  4. 4. Regulation of Clotting a. Antithrombin III- inhibits thrombin (forms irreversible complex with it) Also Blocks: XIIa XIa IXa, Xa heparin – enhances action of Antithrombin III b. Lysis of clot TPA Plasmin CLoT Plasminogen Serine protease

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