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Psoriasis

Psoriasis. A common scaly and inflammatory skin disorder that is both painful and disabling Thought to be an autoimmune disease with a possible genetic link The activation of T cells is the key trigger. Memory T cell. CD8+ cytotoxic (‘killer’) T cell. Thymus. CD8+ T cell. Pre T cells.

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Psoriasis

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  1. Psoriasis slide • A common scaly and inflammatory skin disorder that is both painful and disabling • Thought to be an autoimmune disease with a possible genetic link • The activation of T cells is the key trigger

  2. Memory T cell CD8+ cytotoxic (‘killer’) T cell Thymus CD8+ T cell Pre T cells T suppressor cell CD4+ T helper cell T cells slide

  3. Antigen presenting cell CytotoxicT cell Activated T cell Activation T cell receptor Antigen Activation of cytotoxic T cells slide IL-6, IL-8 TNF- GM-CSF Interferon-

  4. Cytokine Main function TNF (alpha and beta) • Stimulates accumulation of neutrophils and macrophages at sites of inflammation • Stimulates cells to produce proinflammatory cytokines • Induces synthesis of CSF by endothelial cells and fibroblasts • Affects B-lymphocytes, T-lymphocytes and hybridoma cells • Affects cytotoxic T-cells in combination with other factors such as IL-2 and gamma interferon IL-6 • Promotes neutrophil chemotaxis and degranulation IL-8 • Potent species-specific stimulator of bone marrow cells • Stimulates precursor cells of granulocytes, macrophages and eosinophils GM-CSF • Possesses potent anti-viral activity • Has also been shown to stimulate macrophages and natural killer (NK) cells IFN- Common cytokines slide

  5. Proinflammatory cytokines magnify effects IL-1 IL-8 GM-CSF TNF- Epidermis Dermis TNF- activated endothelium Bloodvessel Immunological cascade in psoriasis slide Cytokines increase keratinocyte proliferation, decrease their maturation and trigger inflammation 3. Arrest/spreading 4. Migration into skin 1. Rolling 2. Activation

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